Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort

Corcoran, N. M.E. , Mair, F. S. , Nicholl, B. , Macdonald, S. and Jani, B. D. (2022) Long-term conditions, multimorbidity and colorectal cancer risk in the UK Biobank cohort. Journal of Multimorbidity and Comorbidity, 12, p. 26335565221110123. (doi: 10.1177/26335565221110123) (PMID:36132374) (PMCID:PMC9483970)

[img] Text
272784.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial.



Purpose: Early identification of colorectal cancer (CRC) is an international priority. Multimorbidity (presence of ≥2 long-term conditions (LTCs)) is increasing and the relationship between CRC and LTCs is little-understood. This study explores the relationship between individual LTCs, multimorbidity and CRC incidence and mortality. Methods: Longitudinal analysis of the UK Biobank cohort, participants recruited 2006–2010; N = 500,195; excluding previous CRC at baseline. Baseline data was linked with cancer/mortality registers. Demographic characteristics, lifestyle factors, 43 LTCs, CRC family history, non-CRC cancers, and multimorbidity count were recorded. Variable selection models identified candidate LTCs potentially predictive of CRC outcomes and Cox regression models tested for significance of associations between selected LTCs and outcomes. Results: Participants’ age range: 37–73 (mean age 56.5; 54.5% female). CRC was diagnosed in 3669 (0.73%) participants, and 916 (0.18%) died from CRC during follow-up (median follow-up 7 years). CRC incidence was higher in the presence of heart failure (Hazard Ratio (HR) 1.96, 95% Confidence Interval (CI) 1.13–3.40), diabetes (HR 1.15, CI 1.01–1.32), glaucoma (HR 1.36, CI 1.06–1.74), male cancers (HR 1.44, CI 1.01–2.08). CRC mortality was higher in presence of epilepsy (HR 1.83, CI 1.03–3.26), diabetes (HR 1.32, CI 1.02–1.72), osteoporosis (HR 1.67, CI 1.12–2.58). No significant association was found between multimorbidity (≥2 LTCs) and CRC outcomes. Conclusions: The associations of certain LTCs with CRC incidence and mortality has implications for clinical practice: presence of certain LTCs in patients presenting with CRC symptoms could trigger early investigation and diagnosis. Future research should explore causative mechanisms and patient perspectives.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Jani, Dr Bhautesh and Nicholl, Dr Barbara and Mair, Professor Frances and Macdonald, Professor Sara and Corcoran, Dr Neave
Authors: Corcoran, N. M.E., Mair, F. S., Nicholl, B., Macdonald, S., and Jani, B. D.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care
Journal Name:Journal of Multimorbidity and Comorbidity
Publisher:SAGE Publications
ISSN (Online):2633-5565
Published Online:15 September 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Journal of Multimorbidity and Comorbidity 12: 26335565221110123
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record