The nosological status of unipolar mania and hypomania within UK Biobank according to objective and subjective measures of diurnal rest and activity

Sangha, N., Lyall, L., Wyse, C., Cullen, B. , Whalley, H. C. and Smith, D. J. (2022) The nosological status of unipolar mania and hypomania within UK Biobank according to objective and subjective measures of diurnal rest and activity. Bipolar Disorders, 24(7), pp. 726-738. (doi: 10.1111/bdi.13237) (PMID:35656588)

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Background: There is uncertainty whether unipolar mania is a discrete sub-type of bipolar disorder. Disrupted rest/activity rhythms are a key feature of bipolar disorder (BD) but have not been well characterised in unipolar mania/hypomania (UM). We compared subjective and objective rest/activity patterns, demographic and mental health outcomes across BD, UM and control groups. Methods: UK residents aged 37–73 years were recruited into UK Biobank from 2006 to 2010. BD, UM and control groups were identified via a mental health questionnaire. Demographic, mental health and subjective sleep outcomes were self-reported. Accelerometery data were available for a subset of participants, and objective measures of sleep and activity were derived. Results: A greater proportion of males met UM criteria, and more females were in the BD group. Both BD and UM groups had poor mental health outcomes vs. controls. Objectively measured activity differed between all three groups: UM had highest levels of activity and BD lowest. The UM group had shorter sleep duration compared to controls. Subjective rest/activity measures showed that both mood disorder groups (compared to controls) had later chronotype preference, more disturbed sleep and increased difficulty getting up in the morning. However, the UM group were more likely to report an early chronotype compared to BD and control groups. Conclusions: BD and UM share features in common, but key differences support the proposition that UM may be a distinct and more clinically homogenous disorder. UM was characterised by a higher proportion of males, early chronotype, increased activity and shorter sleep duration.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Sangha, Natasha and Lyall, Dr Laura and Cullen, Dr Breda
Authors: Sangha, N., Lyall, L., Wyse, C., Cullen, B., Whalley, H. C., and Smith, D. J.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Mental Health and Wellbeing
Journal Name:Bipolar Disorders
ISSN (Online):1399-5618
Published Online:02 June 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Bipolar Disorders 24(7): 726-738
Publisher Policy:Reproduced under a Creative Commons licence

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