Evaluation and optimisation of a target-controlled infusion system for administering propofol to dogs as part of a total intravenous anaesthetic technique during dental surgery

Beths, T., Glen, J.B., Reid, J., Monteiro, A.M. and Nolan, A.M. (2001) Evaluation and optimisation of a target-controlled infusion system for administering propofol to dogs as part of a total intravenous anaesthetic technique during dental surgery. Veterinary Record, 148(7), pp. 198-203. (doi: 10.1136/vr.148.7.198)

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Publisher's URL: http://dx.doi.org/10.1136/vr.148.7.198

Abstract

The performance of a modified target-controlled infusion system was investigated in 16 dogs undergoing routine dental work, by comparing the predicted concentrations of propofol in venous blood samples with direct measurements; the optimum targets for the induction and maintenance of anaesthesia were also identified. The performance of a target-controlled infusion system is considered clinically acceptable when the median prediction error, a measure of bias, is not greater than +/-10 to 20 per cent, and the median absolute performance error, a measure of the accuracy, is not greater than 20 to 30 per cent. The results fell within these limits indicating that the system performed adequately. The optimal induction target was 3 microg/ml, and anaesthesia of adequate depth and satisfactory quality was achieved with maintenance targets of between 2.5 and 4.7 microg/ml propofol. The system was easy to use and the quality of anaesthesia was adequate for dental work.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Nolan, Professor Andrea and Monteiro, Dr Ana and Reid, Professor Jacqueline
Authors: Beths, T., Glen, J.B., Reid, J., Monteiro, A.M., and Nolan, A.M.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Veterinary Record
Publisher:B M J Group
ISSN:0042-4900
ISSN (Online):2042-7670

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