Sex chromosome evolution in parasitic nematodes of humans

Foster, J. M. et al. (2020) Sex chromosome evolution in parasitic nematodes of humans. Nature Communications, 11, 1964. (doi: 10.1038/s41467-020-15654-6) (PMID:32327641) (PMCID:PMC7181701)

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Abstract

Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such as Caenorhabditis elegans have an XO sex determination system while others, such as the filarial parasite Brugia malayi, have an XY mechanism. We present a complete B. malayi genome assembly and define Nigon elements shared with C. elegans, which we then map to the genomes of other filarial species and more distantly related nematodes. We find a remarkable plasticity in sex chromosome evolution with several distinct cases of neo-X and neo-Y formation, X-added regions, and conversion of autosomes to sex chromosomes from which we propose a model of chromosome evolution across different nematode clades. The phylum Nematoda offers a new and innovative system for gaining a deeper understanding of sex chromosome evolution.

Item Type:Articles
Additional Information:This project was in part funded by the Burroughs-Wellcome Fund to E.G.; federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services under grant number U19 AI110820 to J.C.D.H., J.M.F., and M.L.M.; the Medical Research Council grant MR/L001020/1 to M.P.; and Wellcome grant 098051 to A.T., J.A.C., M.B.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cotton, Professor James
Authors: Foster, J. M., Grote, A., Mattick, J., Tracey, A., Tsai, Y.-C., Chung, M., Cotton, J. A., Clark, T. A., Geber, A., Holroyd, N., Korlach, J., Li, Y., Libro, S., Lustigman, S., Michalski, M. L., Paulini, M., Rogers, M. B., Teigen, L., Twaddle, A., Welch, L., Berriman, M., Dunning Hotopp, J. C., and Ghedin, E.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Nature Communications
Publisher:Nature Research
ISSN:2041-1723
ISSN (Online):2041-1723
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Nature Communications 11: 1964
Publisher Policy:Reproduced under a Creative Commons License

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