Retrospective analysis of the use of tiludronate in equine practice: safety on 1804 horses, efficacy on 343 horses

Tischmacher, A., Wilford, S., Allen, K., Mitchell, R. D., Parkin, T. and Denoix, J.-M. (2022) Retrospective analysis of the use of tiludronate in equine practice: safety on 1804 horses, efficacy on 343 horses. Journal of Equine Veterinary Science, 115, 104007. (doi: 10.1016/j.jevs.2022.104007) (PMID:35577109)

Abstract

The objective of this retrospective study was to assess the safety and efficacy of a slow IV administration of 1mg/kg tiludronate in a large number of horses. Each horse that received at least one tiludronate-based treatment between 2006 and August 2019 at Virginia Equine Imaging or Fairfield Equine was included in the study. Concomitant medical treatments, preliminary NSAID injection and potential side effects were recorded after each administration. Horses for which follow-up was available over one year were subject to clinical evolution assessment via lameness grade evolution and performance data when available. Collected data suggest excellent tolerance to tiludronate with only 0,9% of the 2497 injections (1804 horses) inducing potential side effects, mild colics being the most frequent. Clinical follow-up was available over more than one year for 343 horses. Most horses (>80%) presented an initial lameness score over 1.5/5, approximately half of the population was sound by 30 days and remained so after a year. Mean lameness score improved by more than 1 grade during the follow-up period compared to initial examination. Performance data were available for 129 horses. One year after treatment, 89 (69%) horses were still competing, 73 (82%) of them at a better or similar level. These data suggest good efficacy of tiludronate over a year after treatment. Despite limitations inherent to any field study, this is the first retrospective study of the use of bisphosphonates in horses combining a large group with long-term follow-ups.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Parkin, Professor Tim
• Authors: Tischmacher, A., Wilford, S., Allen, K., Mitchell, R. D., Parkin, T., and Denoix, J.-M.
• College/School: College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
• Journal Name: Journal of Equine Veterinary Science
• Publisher: Elsevier
• ISSN: 0737-0806
• ISSN (Online): 1542-7412
• Published Online: 13 May 2022
• Copyright Holders: Copyright © 2022 Elsevier Inc.
• First Published: First published in Journal of Equine Veterinary Science 115: 104007
• Publisher Policy: Reproduced in accordance with the publisher copyright policy