Six-canal video head impulse test in patients with labyrinthine and retrolabyrinthine pathology: detecting vestibulo-ocular reflex deficits

Kontorinis, G. , Tailor, H., Tikka, T. and Slim, M.A.M. (2023) Six-canal video head impulse test in patients with labyrinthine and retrolabyrinthine pathology: detecting vestibulo-ocular reflex deficits. Journal of Laryngology and Otology, 137(4), pp. 398-403. (doi: 10.1017/S0022215122001153) (PMID:35570664)

Abstract

Background: Abnormal gains in six-canal video-Head-Impulse-Test (vHIT) are attributed to semicircular canal deficits. However, as vHIT responses are linked to vestibulo-ocular reflex (VOR), we hypothesized that abnormal gains can be due to VOR pathway deficits. Methods: We compared vHIT gains and correlations between them (Mann-Kendall trend test) in 20 patients with superior semi-circular canal dehiscence (SSCD; labyrinthine cause) and 20 side and gender-matched patients with vestibular schwannomas (VS, retrolabyrinthine cause). Results: VS but not SSCD was significantly associated with abnormal lateral (OR: 9.00 (95% CI:1.638;49.44), p:0.011) and posterior canal status (OR: 9.00 (95% CI: 2.151;37.659), p:0.003). In VS we found a statistically significant degree of dependence between all ipsilesional canal vHIT gains; such dependence was not observed in SSCD. Conclusions: VOR gains differ in patients with labyrinthine and retrolabyrinthine disease, suggesting that abnormal gains can indicate not only deficits in the semi-circular canals but also elsewhere along the VOR pathway.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Kontorinis, Mr Georgios
• Authors: Kontorinis, G., Tailor, H., Tikka, T., and Slim, M.A.M.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Journal of Laryngology and Otology
• Publisher: Cambridge University Press
• ISSN: 0022-2151
• ISSN (Online): 1748-5460
• Published Online: 16 May 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Journal of Laryngology and Otology 137(4): 398-403
• Publisher Policy: Reproduced in accordance with the publisher copyright policy