Using Caenorhabditis elegans for functional analysis of genes of parasitic nematodes

Britton, C. and Murray, L. (2006) Using Caenorhabditis elegans for functional analysis of genes of parasitic nematodes. International Journal for Parasitology, 36(6), pp. 651-659. (doi: 10.1016/j.ijpara.2006.02.010) (PMID:16616144)

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Information on the functional genomics of Caenorhabditis elegans has increased significantly in the last few years with the development of RNA interference. In parasitic nematodes, RNA interference has shown some success in gene knockdown but optimisation of this technique will be required before it can be adopted as a reliable functional genomics tool. Comparative studies in C. elegans remain an appropriate alternative for studying the function and regulation of some parasite genes and will be extremely useful for fully exploiting the increasing parasite genome sequence data becoming available.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Murray, Ms Linda and Britton, Professor Collette
Authors: Britton, C., and Murray, L.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:International Journal for Parasitology
ISSN (Online):1879-0135
Published Online:15 March 2006

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
351421Adaptation of caenorhabditis elegans technology to identification and expression of parasite target genesCollette BrittonBiotechnology and Biological Sciences Research Council (BBSRC)S20387Infection Immunity and Inflammation Life Sciences