Successful recognition of protein folds using threading methods biased by sequence similarity and predicted secondary structure

Jones, D. T., Tress, M., Bryson, K. and Hadley, C. (1999) Successful recognition of protein folds using threading methods biased by sequence similarity and predicted secondary structure. Proteins: Structure Function and Bioinformatics, 37(S3), pp. 104-111. (doi: 10.1002/(SICI)1097-0134(1999)37:3+<104::AID-PROT14>3.0.CO;2-P)

Abstract

Analysis of our fold recognition results in the 3rd Critical Assessment in Structure Prediction (CASP3) experiment, using the programs THREADER 2 and GenTHREADER, shows an encouraging level of overall success. Of the 23 submitted predictions, 20 targets showed no clear sequence similarity to proteins of known 3D structure. These 20 targets can be divided into 22 domains, of which, 20 domains either entirely match a previously known fold, or partially match a substantial region of a known fold. Of these 20 domains, we correctly assigned the folds in 10 cases.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Bryson, Dr Kevin
• Authors: Jones, D. T., Tress, M., Bryson, K., and Hadley, C.
• College/School: College of Science and Engineering > School of Computing Science
• Journal Name: Proteins: Structure Function and Bioinformatics
• Publisher: Wiley
• ISSN: 0887-3585
• ISSN (Online): 1097-0134

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