Protein control of membrane and organelle dynamics: insights from the divergent eukaryote Toxoplasma gondii

Ovciarikova, J., Oliveira Souza, R. O., Arrizabalaga, G. and Sheiner, L. (2022) Protein control of membrane and organelle dynamics: insights from the divergent eukaryote Toxoplasma gondii. Current Opinion in Cell Biology, 76, 102085. (doi: 10.1016/j.ceb.2022.102085) (PMID:35569259) (PMCID:PMC9586877)

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Abstract

Integral membrane protein complexes control key cellular functions in eukaryotes by defining membrane-bound spaces within organelles and mediating inter-organelles contacts. Despite the critical role of membrane complexes in cell biology, most of our knowledge is from a handful of model systems, primarily yeast and mammals, while a full functional and evolutionary understanding remains incomplete without the perspective from a broad range of divergent organisms. Apicomplexan parasites are single-cell eukaryotes whose survival depends on organelle compartmentalisation and communication. Studies of a model apicomplexan, Toxoplasma gondii, reveal unexpected divergence in the composition and function of complexes previously considered broadly conserved, such as the mitochondrial ATP synthase and the tethers mediating ER–mitochondria membrane contact sites. Thus, Toxoplasma joins the repertoire of divergent model eukaryotes whose research completes our understanding of fundamental cell biology.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ovciarikova, Miss Jana and Sheiner, Professor Lilach
Authors: Ovciarikova, J., Oliveira Souza, R. O., Arrizabalaga, G., and Sheiner, L.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Current Opinion in Cell Biology
Publisher:Elsevier
ISSN:0955-0674
ISSN (Online):1879-0410
Published Online:12 May 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Current Opinion in Cell Biology 76: 102085
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
307056Lost in translation. A study of the divergent mitochondrial translation pathway of the parasite Toxoplasma gondiiLilach SheinerWellcome Trust (WELLCOTR)217173/Z/19/ZMVLS - Polyomics Facility