Ovciarikova, J., Oliveira Souza, R. O., Arrizabalaga, G. and Sheiner, L. (2022) Protein control of membrane and organelle dynamics: insights from the divergent eukaryote Toxoplasma gondii. Current Opinion in Cell Biology, 76, 102085. (doi: 10.1016/j.ceb.2022.102085) (PMID:35569259) (PMCID:PMC9586877)
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Abstract
Integral membrane protein complexes control key cellular functions in eukaryotes by defining membrane-bound spaces within organelles and mediating inter-organelles contacts. Despite the critical role of membrane complexes in cell biology, most of our knowledge is from a handful of model systems, primarily yeast and mammals, while a full functional and evolutionary understanding remains incomplete without the perspective from a broad range of divergent organisms. Apicomplexan parasites are single-cell eukaryotes whose survival depends on organelle compartmentalisation and communication. Studies of a model apicomplexan, Toxoplasma gondii, reveal unexpected divergence in the composition and function of complexes previously considered broadly conserved, such as the mitochondrial ATP synthase and the tethers mediating ER–mitochondria membrane contact sites. Thus, Toxoplasma joins the repertoire of divergent model eukaryotes whose research completes our understanding of fundamental cell biology.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Ovciarikova, Miss Jana and Sheiner, Professor Lilach |
Authors: | Ovciarikova, J., Oliveira Souza, R. O., Arrizabalaga, G., and Sheiner, L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Current Opinion in Cell Biology |
Publisher: | Elsevier |
ISSN: | 0955-0674 |
ISSN (Online): | 1879-0410 |
Published Online: | 12 May 2022 |
Copyright Holders: | Copyright © 2022 The Authors |
First Published: | First published in Current Opinion in Cell Biology 76: 102085 |
Publisher Policy: | Reproduced under a Creative Commons License |
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