From laboratory to clinic: science commercialization within university-centered entrepreneurial ecosystems

Johnson, D. , Gianiodis, P. T., Harrison, R. T. and Bock, A. J. (2023) From laboratory to clinic: science commercialization within university-centered entrepreneurial ecosystems. R and D Management, 53(1), pp. 3-23. (doi: 10.1111/radm.12535)

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The commercialization of scientific discoveries within the university-industry nexus is multifaceted and complex, characterized by dynamic interactions between multiple agents, organizations, and institutions. These interactions support a university-centered entrepreneurial ecosystem (UCEE). Our study investigates agent-institution dynamics within the UCEE to explore how individual agents seek to commercialize their scientific discoveries. Specifically, relying on 47 narrative interviews, we explore how UCEE agents across three UCEEs in the United States, United Kingdom, and Russia respond and adapt to institutional commercialization mandates during commercialization of their stem cell-based regenerative medicine discoveries. Our findings emphasize the bi-directional relationship between individual agents and institutions within a UCEE, facilitating a much-needed multi-level perspective on academic entrepreneurship research. We extend recent frameworks that propose how the formative stages of the entrepreneurial process – opportunity evolution – influences ecosystem emergence. Specifically, by investigating the latter stages of the entrepreneurial process – how (science-based) opportunities are commercialized within UCEEs – we reveal distinct behavioral responses to science commercialization mandates, which underscore how UCEEs evolve. Furthermore, by explicating the importance of UCEE agent behavior during science commercialization, our study shines an important spotlight onto the microfoundations of science commercialization and UCEEs. Our research imparts important policy implications for institutions tasked with commercializing scientific discoveries and policy makers challenged with developing high growth, sustainable UCEEs.

Item Type:Articles
Additional Information:This work was supported by The Economic and Social Research Council under Grant Number ES/J500136/1. Additional support was also provided by Research and Development Management Association (RADMA).
Keywords:Science commercialization, technology transfer, university-centered entrepreneurial ecosystem (UCEE), entrepreneur-institution dynamics, entrepreneurial behavior, academic entrepreneurship.
Glasgow Author(s) Enlighten ID:Johnson, Dr David
Authors: Johnson, D., Gianiodis, P. T., Harrison, R. T., and Bock, A. J.
College/School:College of Social Sciences > Adam Smith Business School > Management
Research Group:Entrepreneurship, Development and Political Economy
Journal Name:R and D Management
ISSN (Online):1467-9310
Published Online:09 May 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in R and D Management 53(1): 3-23
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190423ESRC Doctoral Training Centre 2011...Mary Beth KneafseyEconomic and Social Research Council (ESRC)ES/J500136/1Research and Innovation Services