Kaposi's sarcoma-associated herpesvirus immune modulation: an overview

Rezaee, S.A.R., Cunningham, C., Davison, A.J. and Blackbourn, D.J. (2006) Kaposi's sarcoma-associated herpesvirus immune modulation: an overview. Journal of General Virology, 87(7), pp. 1781-1804. (doi: 10.1099/vir.0.81919-0) (PMID:16760382)

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Kaposi's sarcoma-associated herpesvirus (KSHV) is the most recently discovered human herpesvirus. It is the aetiological agent of Kaposi's sarcoma (KS), a tumour frequently affecting AIDS patients not receiving treatment. KSHV is also a likely cause of two lymphoproliferative diseases: multicentric Castleman's disease and primary effusion lymphoma. The study of KSHV offers exciting challenges for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host. To facilitate these processes, approximately one-quarter of KSHV genes encode cellular homologues or unique proteins that have immunomodulatory roles in cytokine production, apoptosis, cell signalling and the immunological synapse. The activities of these molecules are considered in the present review and the positions of their genes are mapped from a complete KSHV genome sequence derived from a KS biopsy. The understanding gained enables the significance of different components of the immune response in protection against KSHV infection to be evaluated. It also helps to unravel the complexities of cellular and immunological pathways and offers the potential for exploiting viral immunomodulators and derivatives in disease therapy.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cunningham, Mr Charles and Davison, Professor Andrew
Authors: Rezaee, S.A.R., Cunningham, C., Davison, A.J., and Blackbourn, D.J.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN (Online):1465-2099

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656321Genomics of human cytomegalovirusAndrew DavisonMedical Research Council (MRC)MC_UU_12014/3MVLS III - CENTRE FOR VIRUS RESEARCH