Hierarchical statistical modelling of influenza epidemic dynamics in space and time

Mugglin, A.S., Cressie, N. and Gemmell, I. (2002) Hierarchical statistical modelling of influenza epidemic dynamics in space and time. Statistics in Medicine, 21(18), pp. 2703-2721. (doi: 10.1002/sim.1217)

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Publisher's URL: http://dx.doi.org/10.1002/sim.1217

Abstract

An infectious disease typically spreads via contact between infected and susceptible individuals. Since the small-scale movements and contacts between people are generally not recorded, available data regarding infectious disease are often aggregations in space and time, yielding small-area counts of the number infected during successive, regular time intervals. In this paper, we develop a spatially descriptive, temporally dynamic hierarchical model to be fitted to such data. Disease counts are viewed as a realization from an underlying multivariate autoregressive process, where the relative risk of infection incorporates the space-time dynamic. We take a Bayesian approach, using Markov chain Monte Carlo to compute posterior estimates of all parameters of interest. We apply the methodology to an influenza epidemic in Scotland during the years 1989-1990.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:UNSPECIFIED
Authors: Mugglin, A.S., Cressie, N., and Gemmell, I.
Subjects:R Medicine > RA Public aspects of medicine
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Centre for Population and Health Sciences
Journal Name:Statistics in Medicine
ISSN:0277-6715

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