Lawrence, M., Wiesheu, R. and Coffelt, S. B. (2022) The duplexity of unconventional T cells in cancer. International Journal of Biochemistry and Cell Biology, 146, 106213. (doi: 10.1016/j.biocel.2022.106213) (PMID:35447350)
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Abstract
Unconventional T cells and their involvement in cancer are understudied in comparison to conventional T cells, but recent findings indicate that these cells play important roles in both cancer progression and inhibition. Here, we briefly review the dichotomous role of three unconventional T cell lineages: γδ T cells, MAIT cells and NKT cells. Studies using mouse models of cancer show how this unconventional trilogy interacts with cancer epithelial cells and other immune cell populations during tumour evolution. These reports highlight various potential avenues for therapeutic intervention that may be exploited for cancer immunotherapy.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by grants from Breast Cancer Now (2019DecPhD1349) and Pancreatic Cancer UK (2017FutureLeadersAcademy). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Wiesheu, Robert and Lawrence, Mark and Coffelt, Dr Seth |
| Authors: | Lawrence, M., Wiesheu, R., and Coffelt, S. B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
| Journal Name: | International Journal of Biochemistry and Cell Biology |
| Publisher: | Elsevier |
| ISSN: | 1357-2725 |
| ISSN (Online): | 1878-5875 |
| Published Online: | 18 April 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in International Journal of Biochemistry and Cell Biology 146: 106213 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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