The role of angiogenesis and arteriogenesis in myocardial infarction and coronary revascularization

Spadaccio, C., Nenna, A., Rose, D., Piccirillo, F., Nusca, A., Grigioni, F., Chello, M. and Vlahakes, G. J. (2022) The role of angiogenesis and arteriogenesis in myocardial infarction and coronary revascularization. Journal of Cardiovascular Translational Research, 15(5), pp. 1024-1048. (doi: 10.1007/s12265-022-10241-0) (PMID:35357670)

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Abstract

Surgical myocardial revascularization is associated with long-term survival benefit in patients with multivessel coronary artery disease. However, the exact biological mechanisms underlying the clinical benefits of myocardial revascularization have not been elucidated yet. Angiogenesis and arteriogenesis biologically leading to vascular collateralization are considered one of the endogenous mechanisms to preserve myocardial viability during ischemia, and the presence of coronary collateralization has been regarded as one of the predictors of long-term survival in patients with coronary artery disease (CAD). Some experimental studies and indirect clinical evidence on chronic CAD confirmed an angiogenetic response induced by myocardial revascularization and suggested that revascularization procedures could constitute an angiogenetic trigger per se. In this review, the clinical and basic science evidence regarding arteriogenesis and angiogenesis in both CAD and coronary revascularization is analyzed with the aim to better elucidate their significance in the clinical arena and potential therapeutic use.

Item Type:Articles
Keywords:Myocardial infarction, angiogenesis, coronary artery bypass graft, percutaneous coronary intervention, myocardial revascularization, arteriogenesis.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Spadaccio, Dr Cristiano
Authors: Spadaccio, C., Nenna, A., Rose, D., Piccirillo, F., Nusca, A., Grigioni, F., Chello, M., and Vlahakes, G. J.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Journal of Cardiovascular Translational Research
Publisher:Springer
ISSN:1937-5387
ISSN (Online):1937-5395
Published Online:31 March 2022

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