Medina, A., Bellec, K. , Polcownuk, S. and Cordero, J. B. (2022) Investigating local and systemic intestinal signalling in health and disease with Drosophila. Disease Models and Mechanisms, 15(3), dmm049332. (doi: 10.1242/dmm.049332) (PMID:35344037) (PMCID:PMC8990086)
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Abstract
Whole-body health relies on complex inter-organ signalling networks that enable organisms to adapt to environmental perturbations and to changes in tissue homeostasis. The intestine plays a major role as a signalling centre by producing local and systemic signals that are relayed to the body and that maintain intestinal and organismal homeostasis. Consequently, disruption of intestinal homeostasis and signalling are associated with systemic diseases and multi-organ dysfunction. In recent years, the fruit fly Drosophila melanogaster has emerged as a prime model organism to study tissue-intrinsic and systemic signalling networks of the adult intestine due to its genetic tractability and functional conservation with mammals. In this Review, we highlight Drosophila research that has contributed to our understanding of how the adult intestine interacts with its microenvironment and with distant organs. We discuss the implications of these findings for understanding intestinal and whole-body pathophysiology, and how future Drosophila studies might advance our knowledge of the complex interplay between the intestine and the rest of the body in health and disease.
Item Type: | Articles |
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Additional Information: | Funding: Work in the Cordero laboratory is funded by a Wellcome Trust and Royal Society Sir Henry Dale Fellowship (104103/Z/14/Z) and a Cancer Research UK (CRUK) Pioneer Award (A29265) to J.B.C., and CRUK core funding through the CRUK Beatson Institute (A17196). |
Keywords: | General Biochemistry, Genetics and Molecular Biology, Immunology and Microbiology (miscellaneous), Medicine (miscellaneous), Neuroscience (miscellaneous) |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Medina, André and Polcownuk, Dr Sofia and Cordero, Professor Julia and Bellec, Miss Karen |
Authors: | Medina, A., Bellec, K., Polcownuk, S., and Cordero, J. B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Disease Models and Mechanisms |
Publisher: | Company of Biologists Ltd. |
ISSN: | 1754-8403 |
ISSN (Online): | 1754-8411 |
Published Online: | 28 March 2022 |
Copyright Holders: | Copyright © 2022 The Author(s) |
First Published: | First published in Disease Models and Mechanisms 15(3): dmm049332 |
Publisher Policy: | Reproduced under a Creative Commons License |
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