Untargeted metabolomics reveals metabolic stress alleviation by prepartum exercise in transition dairy cows

Luo, Z. et al. (2022) Untargeted metabolomics reveals metabolic stress alleviation by prepartum exercise in transition dairy cows. Metabolites, 12(4), 309. (doi: 10.3390/metabo12040309) (PMID:35448496) (PMCID:PMC9028530)

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Abstract

Prepartum exercise (PA) has been proposed as a strategy for the peripartum management of dairy cows; however, the mechanism by which PA affects metabolism has not been elucidated. Here, we investigated the metabolic changes in transition dairy cows with PA. Holstein transition multiparous dairy cows were assigned to an exercise (n = 12) or a control (n = 12) group; the cows in the exercise group walked for a targeted 45 min at 3.25 km/h, two times a day. Plasma non-esterified fatty acid (NEFA), β-hydroxybutyric acid (BHBA), glucose, and triglyceride levels were measured, and metabolic profiles were analyzed using untargeted mass spectrometry. Compared with those in the control group, the concentrations of NEFA at −7 d, glucose at 0 d, and BHBA at +7 d relative to calving were considerably decreased in the exercise group. Untargeted metabolomics analysis revealed differences in the levels of key metabolites, including kynurenine, tryptophan, homovanillic acid, dopamine, cis-9-palmitoleic acid, and palmitic acid, between the exercise and control group cows. This study suggests that PA may decrease homovanillic acid and cis-9-palmitoleic acid levels and increase tryptophan levels to alleviate the metabolic stress in dairy cows during calving, thereby improving postpartum health.

Item Type:Articles
Additional Information:This study was supported by the National Natural Science Foundation of China (No. 31660731) and the Key R&D Program Supported by the Department of Science and Technology of Gansu Province (No. 20YF8NA029).
Keywords:Prepartum exercise, transition dairy cow, metabolomics, metabolic stress.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Huang, Yixin
Creator Roles:
Huang, Y.Conceptualization, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review and editing
Authors: Luo, Z., Huang, Y., Ma, L., Jiang, J., Luo, Q., Yang, Z., Yong, K., Shen, L., Yu, S., Yao, X., Tao, J., and Cao, S.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Metabolites
Publisher:MDPI
ISSN:2218-1989
ISSN (Online):2218-1989
Published Online:31 March 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Metabolites 12(4): 309
Publisher Policy:Reproduced under a Creative Commons License

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