Thermoregulation in the life cycle of nematodes

Devaney, E. (2006) Thermoregulation in the life cycle of nematodes. International Journal for Parasitology, 36(6), pp. 641-649. (doi: 10.1016/j.ijpara.2006.02.006)

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An unanswered question in the biology of many parasites is the mechanism by which environmental (or external) and intrinsic signals are integrated to determine the switch from one developmental stage to the next. This is particularly pertinent for nematode parasites, many of which have a free-living stage in the environment prior to infection of the mammalian host, or for parasites such as filarial nematodes, which utilise an insect vector for transmission. The environmental changes experienced by a parasite upon infection of a mammalian host are extremely complex and poorly understood. However, the ability of a parasite to sense its new environment must be intrinsically linked to its developmental programme, as progression of the life cycle is dependent upon the infection event. In this review, the relationship between temperature and development in filarial nematodes and in the free-living species Caenorhabditis elegans is summarised, with a focus on the role of heat shock factor and heat shock protein 90 in the nematode life cycle.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Devaney, Professor Eileen
Authors: Devaney, E.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:International Journal for Parasitology
ISSN (Online):1879-0135
Published Online:13 March 2006

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