Associations of haemostatic variables with cardiovascular disease and total mortality - the Glasgow MONICA Study

Lowe, G., Peters, S. A.E., Rumley, A., Tunstall-Pedoe, H. and Woodward, M. (2022) Associations of haemostatic variables with cardiovascular disease and total mortality - the Glasgow MONICA Study. TH Open, 6(2), e107-e113. (doi: 10.1055/a-1789-4896)

Abstract

The associations of plasma levels of haemostatic factors, other than fibrinogen, with risks of cardiovascular disease and all-cause mortality are not well defined. In two phases of the Glasgow MONICA Study, we assayed coagulation factors (VII, VIII, IX and von Willebrand factor, VWF), coagulation inhibitors (antithrombin, protein C, protein S), coagulation activation markers (prothrombin F1+2, thrombin-antithrombin [TAT] complexes, D-dimer), and the fibrinolytic factors tissue plasminogen activator antigen (t-PA) and plasminogen activator inhibitor (PAI-1). Over 15-20 years, we followed-up between 382 and 1123 men and women aged 30-74 years, without baseline CVD, for risks of CVD and mortality. Age and sex adjusted hazard ratios (HRs) for CVD (top third versus bottom third) were significant only for Factor VIII (1.30; 95% CI 1.06, 1.58) and Factor IX (1.18; 1.01, 1.39); these HRs were attenuated by further adjustment for CVD risk factors: 1.17; 0.94, 1.46, and 1.07; 0.92, 1.25, respectively. In contrast, Factor VIII, D-dimer and t-PA were strongly associated with mortality after full risk factor adjustment: respectively, 1.63 (1.35, 1.96), 2.34 (1.26; 4.35) and 2.81 (1.43, 5.54). Further studies, including meta-analyses, are required to assess the associations of these haemostatic factors with the risks of stroke and heart disease and causes of mortality.

• Item Type: Articles
• Additional Information: This study was funded by the Chief Scientist Office, Department of Health, Scottish Office.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Woodward, Professor Mark and Rumley, Dr Ann and Lowe, Professor Gordon
• Authors: Lowe, G., Peters, S. A.E., Rumley, A., Tunstall-Pedoe, H., and Woodward, M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: TH Open
• Publisher: Thieme Open
• ISSN: 2512-9465
• ISSN (Online): 2512-9465
• Published Online: 04 March 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in TH Open 6(2): e107-e113
• Publisher Policy: Reproduced under a Creative Commons License