Gaba, F., Tipping, W. J., Salji, M. , Faulds, K., Graham, D. and Leung, H. Y. (2022) Raman spectroscopy in prostate cancer: techniques, applications and advancements. Cancers, 14(6), 1535. (doi: 10.3390/cancers14061535) (PMID:35326686) (PMCID:PMC8946151)
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Abstract
Optical techniques are widely used tools in the visualisation of biological species within complex matrices, including biopsies, tissue resections and biofluids. Raman spectroscopy is an emerging analytical approach that probes the molecular signature of endogenous cellular biomolecules under biocompatible conditions with high spatial resolution. Applications of Raman spectroscopy in prostate cancer include biopsy analysis, assessment of surgical margins and monitoring of treatment efficacy. The advent of advanced Raman imaging techniques, such as stimulated Raman scattering, is creating opportunities for real-time in situ evaluation of prostate cancer. This review provides a focus on the recent preclinical and clinical achievements in implementing Raman-based techniques, highlighting remaining challenges for clinical applications. The research and clinical results achieved through in vivo and ex vivo Raman spectroscopy illustrate areas where these evolving technologies can be best translated into clinical practice.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by the Medical Research Council Clinical Research Training Fellow-ship awarded to MS (MR/L017997/1) and CRUK Beatson Institute core funding (C596/A31287) and CRUK core group awarded to HYL (A15151). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Salji, Mr Mark and Gaba, Dr Fortis and Leung, Professor Hing and Graham, Professor Duncan |
| Creator Roles: | Gaba, F.Investigation, Writing – original draft Salji, M.Conceptualization, Investigation Graham, D.Writing – review and editing Leung, H. Y.Conceptualization, Writing – review and editing |
| Authors: | Gaba, F., Tipping, W. J., Salji, M., Faulds, K., Graham, D., and Leung, H. Y. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing College of Science and Engineering > School of Chemistry |
| Journal Name: | Cancers |
| Publisher: | MDPI |
| ISSN: | 2072-6694 |
| ISSN (Online): | 2072-6694 |
| Copyright Holders: | Copyright © 2022 by the Authors |
| First Published: | First published in Cancers 14(6):1535 |
| Publisher Policy: | Reproduced under a Creative Commons licence |
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