Anatomical variation of the aorta in the west of Scotland – a population with high cardiovascular disease burden. Implications for stent design and deployment

Allardyce, H., Shepherd, E. and Bailey, E. (2023) Anatomical variation of the aorta in the west of Scotland – a population with high cardiovascular disease burden. Implications for stent design and deployment. Journal of Anatomy, 242(1), pp. 112-120. (doi: 10.1111/joa.13652) (PMID:35301720) (PMCID:PMC9773165)

[img] Text
266758.pdf - Published Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.



The prevalence and complexity of cardiovascular disease (CVD) in the West of Scotland are high with the aortic arch and abdominal aorta, particularly at increased risk of cardiovascular pathology. Stent deployment can be key in preventing further cardiovascular events, however, current stent design does not account for complex advanced CVD in these areas. This cadaveric study aimed to provide anatomical measurements requested by manufacturers to improve stent design and deployment in this target population. Nine cadavers (six females and three males; age range = 82.7 ± 10.4 years) from the West of Scotland were dissected to expose the aortic arch and abdominal aorta. Digital callipers and protractors were used to collect data on vessel diameters (including taper), branch spacing, angles and presence of collaterals. CVD was present in all cadavers and ranged from mild plaque presence to aortic dissections. One possessed a bovine aortic arch variation. Supra-aortic vessels were approximately equally spaced, but the left common carotid had the most acute branching angle. Angulation of the arch from the coronal plane positively correlated with a deviation of the left subclavian artery (LSA) from the sternal midline (Spearman's coefficient r = 0.82, p = 0.01) which may impact surgical access. The origin of the vertebral artery on the LSA was also highly variable. The diameter of the descending aorta decreased along its length from the aortic hiatus to superior mesenteric by 21 ± 10% indicating a high degree of taper. The artery of Adamkiewicz was present in 33% and additional renal collaterals were present in 22%. 66% had tortuous vessels in the abdominal region. These results highlight the need for more data to aid the refinement of stent-graft design and deployment methods to ensure successful surgical intervention in this population.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Bailey, Dr Emma
Creator Roles:
Bailey, E.Conceptualization, Writing – original draft, Writing – review and editing
Authors: Allardyce, H., Shepherd, E., and Bailey, E.
College/School:College of Medical Veterinary and Life Sciences > School of Life Sciences
Journal Name:Journal of Anatomy
ISSN (Online):1469-7580
Published Online:17 March 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Journal of Anatomy 242(1): 112-120
Publisher Policy:Reproduced under a Creative Commons licence

University Staff: Request a correction | Enlighten Editors: Update this record