Lymphangiosarcoma in the nictitating membrane of a horse

Puff, C., Herder, V. , Philipp, A. and Baumgärtner, W. (2008) Lymphangiosarcoma in the nictitating membrane of a horse. Journal of Veterinary Diagnostic Investigation, 20(1), pp. 108-110. (doi: 10.1177/104063870802000124) (PMID:18182523)

Abstract

A 15-year-old Haflinger gelding presented with a mass in the left nictitating membrane. Two biopsies and the excised nictitating membrane were taken at different time points as a result of reoccurrence of the mass and submitted for histopathologic evaluation. The horse was euthanized as a result of poor prognosis following the reoccurrence of the mass after surgical removal. Histologically, the mass consisted of dilated, thin-walled vascular clefts and channels, lined by flattened to cuboidal endothelial cells with moderate cellular pleomorphism. There was up to 1 mitotic figure per high power field. The channels were empty or contained few erythrocytes. In the collagen-rich stroma, few lymphocytes, focal follicular lymphoid aggregations, and marked lymphangiectasia were observed. Immunohistochemically, the neoplastic cells stained positive for vimentin and partially positive for factor VIII-related antigen. Ultrastructural analysis revealed discontinuous endothelial lining vascular channels that partially lacked a basal membrane. Based on the histopathologic, immunohistochemical, and ultrastructural features lymphangiosarcoma was diagnosed.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Herder, Dr Vanessa
• Authors: Puff, C., Herder, V., Philipp, A., and Baumgärtner, W.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: Journal of Veterinary Diagnostic Investigation
• Publisher: SAGE Publications
• ISSN: 1040-6387
• ISSN (Online): 1943-4936
• Published Online: 01 January 2008