Sex differences in the prevalence, outcomes and management of hypertension

Connelly, P. J. , Currie, G. and Delles, C. (2022) Sex differences in the prevalence, outcomes and management of hypertension. Current Hypertension Reports, 24(6), pp. 185-192. (doi: 10.1007/s11906-022-01183-8) (PMID:35254589) (PMCID:PMC9239955)

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Purpose of Review: To review recent data on sex differences in the prevalence, outcomes and management of hypertension. Recent Findings: Although hypertension is overall more common in males, females experience a much sharper incline in blood pressure from the third decade of life and consequently the prevalence of hypertension accelerates comparatively with age. Mechanisms responsible for these blood pressure trajectories may include the sustained vascular influence of hypertensive disorders of pregnancy, interactions between the renin–angiotensin–aldosterone system and sex hormones or even psychosocial gendered factors such as socioeconomic deprivation. Moreover, the impact of hypertension is not uniform and females are at higher risk of developing a multitude of adverse cardiovascular outcomes at lower blood pressure thresholds. Summary: Blood pressure is a sexually dimorphic trait and although significant differences exist in the prevalence, pathophysiology and outcomes of hypertension in males and females, limited data exist to support sex-specific blood pressure targets.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Delles, Professor Christian and Currie, Dr Gemma and Connelly, Dr Paul
Authors: Connelly, P. J., Currie, G., and Delles, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Current Hypertension Reports
ISSN (Online):1534-3111
Published Online:07 March 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Current Hypertension Reports 24(6): 185-192
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303944BHF Centre of ExcellenceColin BerryBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science