Evaluation of clinical prognostic variables on short-term outcome for colorectal cancer surgery: an overview and minimum dataset

Cheong, C. M., Golder, A. M. , Horgan, P. D. , McMillan, D. C. and Roxburgh, C. S.D. (2022) Evaluation of clinical prognostic variables on short-term outcome for colorectal cancer surgery: an overview and minimum dataset. Cancer Treatment and Research Communications, 31, 100544. (doi: 10.1016/j.ctarc.2022.100544) (PMID:35248885)

Abstract

Introduction Surgery for colorectal cancer is associated with post-operative morbidity and mortality. Multiple systematic reviews have reported on individual factors affecting short-term outcome following surgical resection. This umbrella review aims to synthesize the available evidence on host and other factors associated with short-term post-operative complications. Methods A comprehensive search identified systematic reviews reporting on short-term outcomes following colorectal cancer surgery using PubMed, Cochrane Database of Systematic Reviews and Web of Science from inception to 8th September 2020. All reported clinicopathological variables were extracted from published systematic reviews. Results The present overview identified multiple validated factors affecting short-term outcomes in patients undergoing colorectal cancer resection. In particular, factors consistently associated with post-operative outcome differed with the type of complication; infective, non-infective or mortality. A minimum dataset was identified for future studies and included pre-operative age, sex, diabetes status, body mass index, body composition (sarcopenia, visceral obesity) and functional status (ASA, frailty). A recommended dataset included antibiotic prophylaxis, iron therapy, blood transfusion, erythropoietin, steroid use, enhance recovery programme and finally potential dataset included measures of the systemic inflammatory response Conclusion A minimum dataset of mandatory, recommended, and potential baseline variables to be included in studies of patients undergoing colorectal cancer resection is proposed. This will maximise the benefit of such study datasets.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Cheong, Miss Chee Mei and Horgan, Professor Paul and Golder, Mr Allan and Roxburgh, Professor Campbell and McMillan, Professor Donald

Creator Roles

McMillan, D.: Conceptualization, Supervision, Writing – review and editing
Cheong, C. M.: Investigation, Methodology, Writing – original draft
Golder, A.: Methodology, Writing – review and editing
Roxburgh, C.: Supervision, Writing – review and editing
Horgan, P.: Resources

• Authors: Cheong, C. M., Golder, A. M., Horgan, P. D., McMillan, D. C., and Roxburgh, C. S.D.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Cancer Treatment and Research Communications
• Publisher: Elsevier
• ISSN: 2468-2942
• ISSN (Online): 2468-2942
• Published Online: 01 March 2022
• Copyright Holders: Copyright © 2022 The Authors
• First Published: First published in Cancer Treatment and Research Communications 31:100544
• Publisher Policy: Reproduced under a Creative Commons licence