Rossitto, G. and Delles, C. (2022) Does excess tissue sodium storage regulate blood pressure? Current Hypertension Reports, 24(5), pp. 115-122. (doi: 10.1007/s11906-022-01180-x) (PMID:35192140) (PMCID:PMC9142429)
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Abstract
Purpose of Review: The regulation of blood pressure is conventionally conceptualised into the product of “circulating blood volume” and “vasoconstriction components”. Over the last few years, however, demonstration of tissue sodium storage challenged this dichotomous view. Recent Findings: We review the available evidence pertaining to this phenomenon and the early association made with blood pressure; we discuss open questions regarding its originally proposed hypertonic nature, recently challenged by the suggestion of a systemic, isotonic, water paralleled accumulation that mirrors absolute or relative extracellular volume expansion; we present the established and speculate on the putative implications of this extravascular sodium excess, in either volume-associated or -independent form, on blood pressure regulation; finally, we highlight the prevalence of high tissue sodium in cardiovascular, metabolic and inflammatory conditions other than hypertension. Summary: We conclude on approaches to reduce sodium excess and on the potential of emerging imaging technologies in hypertension and other conditions.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Rossitto, Dr Giacomo and Delles, Professor Christian |
Authors: | Rossitto, G., and Delles, C. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Current Hypertension Reports |
Publisher: | Springer |
ISSN: | 1522-6417 |
ISSN (Online): | 1534-3111 |
Published Online: | 22 February 2022 |
Copyright Holders: | Copyright © 2022 The Authors |
First Published: | First published in Current Hypertension Reports 24(5): 115-122 |
Publisher Policy: | Reproduced under a Creative Commons License |
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