Does excess tissue sodium storage regulate blood pressure?

Rossitto, G. and Delles, C. (2022) Does excess tissue sodium storage regulate blood pressure? Current Hypertension Reports, 24(5), pp. 115-122. (doi: 10.1007/s11906-022-01180-x) (PMID:35192140) (PMCID:PMC9142429)

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Purpose of Review: The regulation of blood pressure is conventionally conceptualised into the product of “circulating blood volume” and “vasoconstriction components”. Over the last few years, however, demonstration of tissue sodium storage challenged this dichotomous view. Recent Findings: We review the available evidence pertaining to this phenomenon and the early association made with blood pressure; we discuss open questions regarding its originally proposed hypertonic nature, recently challenged by the suggestion of a systemic, isotonic, water paralleled accumulation that mirrors absolute or relative extracellular volume expansion; we present the established and speculate on the putative implications of this extravascular sodium excess, in either volume-associated or -independent form, on blood pressure regulation; finally, we highlight the prevalence of high tissue sodium in cardiovascular, metabolic and inflammatory conditions other than hypertension. Summary: We conclude on approaches to reduce sodium excess and on the potential of emerging imaging technologies in hypertension and other conditions.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Rossitto, Dr Giacomo and Delles, Professor Christian
Authors: Rossitto, G., and Delles, C.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Current Hypertension Reports
ISSN (Online):1534-3111
Published Online:22 February 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Current Hypertension Reports 24(5): 115-122
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
303944BHF Centre of ExcellenceColin BerryBritish Heart Foundation (BHF)RE/18/6/34217CAMS - Cardiovascular Science