Magnetic resonance imaging-based scores of small vessel diseases: associations with intracerebral haemorrhage location

Schwarz, G. et al. (2022) Magnetic resonance imaging-based scores of small vessel diseases: associations with intracerebral haemorrhage location. Journal of the Neurological Sciences, 434, 120165. (doi: 10.1016/j.jns.2022.120165) (PMID:35121207)

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Abstract

Introduction: Total small vessel disease (SVD) score and cerebral amyloid angiopathy (CAA) score are magnetic resonance imaging-based composite scores built to preferentially capture deep perforator arteriopathy-related and CAA-related SVD burden, respectively. Non-lobar intracerebral haemorrhage (ICH) is related to deep perforator arteriopathy, while lobar ICH can be associated with deep perforator arteriopathy or CAA; however, the associations between ICH location and these scores are not established. Methods: In this post-hoc analysis from a prospective cohort study, we included 153 spontaneous non-cerebellar ICH patients. Wald test, univariable and multivariable logistic regression analysis were performed to investigate the association between each score (and individual score components) and ICH location. Results: Total SVD score was associated with non-lobar ICH location (Wald test: unadjusted, p = 0.017; adjusted, p = 0.003); however, no individual component of total SVD score was significantly associated with non-lobar ICH. CAA score was not significantly associated with lobar location (Wald test: unadjusted, p = 0.056; adjusted, p = 0.126); cortical superficial siderosis (OR 8.85 [95%CI 1.23–63.65], p = 0.030) and ≥ 2 strictly lobar microbleeds (OR 1.63 [95%CI 1.04–2.55], p = 0.035) were related with lobar ICH location, while white matter hyperintensities showed an inverse relation (OR 0.53 [95%CI 0.26–1.08; p = 0.081]). Conclusions: Total SVD score was associated with non-lobar ICH location. The lack of significant association between CAA score and lobar ICH may in part be due to the mixed aetiology of lobar ICH, and to the inclusion of white matter hyperintensities, a non-specific marker of SVD type, in the CAA score.

Item Type:Articles
Keywords:MRI-based score, intracerebral haemorrhage, cerebral amyloid angiopathy, CAA score, total SVD score, small vessel disease.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Muir, Professor Keith
Authors: Schwarz, G., Banerjee, G., Hostettler, I. C., Ambler, G., Seiffge, D. J., Brookes, T. S., Wilson, D., Cohen, H., Yousry, T., Salman, R. A.-S., Lip, G. Y.H., Brown, M. M., Muir, K. W., Houlden, H., Jäger, R., Werring, D. J., and Staals, J.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Journal of the Neurological Sciences
Publisher:Elsevier
ISSN:0022-510X
ISSN (Online):1878-5883
Published Online:24 January 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Journal of the Neurological Sciences 434: 120165
Publisher Policy:Reproduced under a Creative Commons License

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