Cyclic AMP signaling in trypanosomatids

Naula, C. and Seebeck, T. (2000) Cyclic AMP signaling in trypanosomatids. Parasitology Today, 16(1), pp. 35-38. (doi: 10.1016/s0169-4758(99)01582-3) (PMID:10637587)

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Curative interference with signal transduction pathways is a spectacularly successful concept in many domains of modern pharmacology; indeed, the ‘wonder drug’ Viagra is but a humble inhibitor of a cyclic GMP (cGMP)-specific phosphodiesterase and, thus, interferes with cGMP-signaling in a strategic organ. In fact, about half of the 100 most successful drugs currently on the market act through modulating cellular signal transduction. Despite these encouraging findings, signal transduction pathways as potential drug targets in trypanosomatids have remained largely unexplored. However, what little is known indicates that adenylyl cyclases of trypanosomatids, and probably other enzymes of the cyclic nucleotide signaling pathways, are significantly different from their mammalian counterparts. Here, Christina Naula and Thomas Seebeck summarize what is known about cAMP signal transduction in trypanosomatids.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Naula, Dr Christina
Authors: Naula, C., and Seebeck, T.
College/School:College of Medical Veterinary and Life Sciences
Journal Name:Parasitology Today
ISSN (Online):1471-5007
Published Online:14 February 2000

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