Burden, A. D., Choon, S. E., Gottlieb, A. B., Navarini, A. A. and Warren, R. B. (2022) Clinical disease measures in generalized pustular psoriasis. American Journal of Clinical Dermatology, 23(Suppl1), pp. 39-50. (doi: 10.1007/s40257-021-00653-0) (PMID:35061231) (PMCID:PMC8801406)
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Abstract
Generalized pustular psoriasis (GPP) is a rare neutrophilic skin condition characterized by episodes of widespread eruption of sterile macroscopic pustules that can be associated with systemic inflammation. The rarity of GPP and its heterogeneous cutaneous and extracutaneous symptoms pose considerable challenges to the development and adoption of comprehensive accurate disease measures for the routine clinical assessment of disease severity and the evaluation of new treatments in clinical trials. Psoriasis disease measures remain among the most commonly used methods for evaluating patients with GPP, despite their limitations owing to a lack of assessment of pustules (a hallmark of GPP), systemic inflammation, and disease symptoms. The adaptation of psoriasis disease measures and the development of assessment tools specific for GPP severity will enable more effective and accurate monitoring of patients with GPP and enhance the clinical development of new therapies. Further clinical validation of recently developed modified assessment tools, such as the Generalized Pustular Psoriasis Physician Global Assessment and the Generalized Pustular Psoriasis Area and Severity Index, and international consensus on using quantitative tools and patient-reported outcome measures in the development of new treatments are needed to advance patient care.
| Item Type: | Articles |
|---|---|
| Additional Information: | RBW is supported by the Manchester NIHR Biomedical Research Centre. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Burden, Professor David |
| Authors: | Burden, A. D., Choon, S. E., Gottlieb, A. B., Navarini, A. A., and Warren, R. B. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | American Journal of Clinical Dermatology |
| Publisher: | Springer |
| ISSN: | 1175-0561 |
| ISSN (Online): | 1179-1888 |
| Published Online: | 21 January 2022 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in American Journal of Clinical Dermatology 23(Suppl 1): 39-50 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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