Olsson, A. M. et al. (2022) miR-155 overexpressing monocytes resemble HLA highISG15 + synovial tissue macrophages from patients with rheumatoid arthritis and induce polyfunctional CD4+ T cell activation. Clinical and Experimental Immunology, 207(2), pp. 188-198. (doi: 10.1093/cei/uxab016) (PMID:35020867) (PMCID:PMC8982969)
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Abstract
MicroRNAs (miRs) are known to regulate pro-inflammatory effector functions of myeloid cells, and miR dysregulation is implicated in rheumatoid arthritis (RA), a condition characterized by inflammation and destruction of the joints. We showed previously that miR-155 is increased in myeloid cells in RA and induces pro-inflammatory activation of monocytes and macrophages; however, its role at the interface between innate and adaptive immunity was not defined. Here, RNA-sequencing revealed that overexpression of miR-155 in healthy donor monocytes conferred a specific gene profile which bears similarities to that of RA synovial fluid-derived CD14+ cells and HLAhighISG15+ synovial tissue macrophages, both of which are characterized by antigen-presenting pathways. In line with this, monocytes in which miR-155 was overexpressed, displayed increased expression of HLA-DR and both co-stimulatory and co-inhibitory molecules, and induced activation of polyfunctional T cells. Together, these data underpin the notion that miR-155-driven myeloid cell activation in the synovium contributes not only to inflammation but may also influence the adaptive immune response.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Kurowska-Stolarska, Professor Mariola and MacDonald, Miss Lucy and Somma, Domenico |
Authors: | Olsson, A. M., Povoleri, G. A.M., Somma, D., Ridley, M. L., Rizou, T., Lalnunhlimi, S., MacDonald, L., Rajasekhar, M., Martinez-Nunez, R. T., Kurowska-Stolarska, M., and Taams, L. S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Research Centre: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity > Centre for Immunobiology |
Journal Name: | Clinical and Experimental Immunology |
Publisher: | Oxford University Press |
ISSN: | 0009-9104 |
ISSN (Online): | 1365-2249 |
Published Online: | 30 November 2021 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in Clinical and Experimental Immunology 207(2): 188-198 |
Publisher Policy: | Reproduced under a Creative Commons License |
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