Remnants, LDL, and the quantification of lipoprotein-associated risk in atherosclerotic cardiovascular disease

Packard, C. J. (2022) Remnants, LDL, and the quantification of lipoprotein-associated risk in atherosclerotic cardiovascular disease. Current Atherosclerosis Reports, 24(3), pp. 133-142. (doi: 10.1007/s11883-022-00994-z) (PMID:35175548)

Abstract

Purpose of Review: Implementation of intensive LDL cholesterol (LDL-C) lowering strategies and recognition of the role of triglyceride-rich lipoproteins (TRL) in atherosclerosis has prompted re-evaluation of the suitability of current lipid profile measurements for future clinical practice. Recent Findings: At low concentrations of LDL-C (< 1.8 mmol/l/70 mg/dl), the Friedewald equation yields estimates with substantial negative bias. New equations provide a more accurate means of calculating LDL-C. Recent reports indicate that the increase in risk per unit increment in TRL/remnant cholesterol may be greater than that of LDL-C. Hence, specific measurement of TRL/remnant cholesterol may be of importance in determining risk. Non-HDL cholesterol and plasma apolipoprotein B have been shown in discordancy analyses to identify individuals at high risk even when LDL-C is low. Summary: There is a need to adopt updated methods for determining LDL-C and to develop better biomarkers that more accurately reflect the abundance of TRL remnant particles.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Packard, Professor Chris
• Authors: Packard, C. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Current Atherosclerosis Reports
• Publisher: Springer
• ISSN: 1523-3804
• ISSN (Online): 1534-6242
• Published Online: 17 February 2022
• Copyright Holders: Copyright © 2022 The Author
• First Published: First published in Current Atherosclerosis Reports 24(3): 133-142
• Publisher Policy: Reproduced under a Creative Commons License