Muscle protein synthesis and muscle/metabolic responses to resistance exercise training in South Asian and White European men

Aba Alkhayl, F. F. et al. (2022) Muscle protein synthesis and muscle/metabolic responses to resistance exercise training in South Asian and White European men. Scientific Reports, 12, 2469. (doi: 10.1038/s41598-022-06446-7) (PMID:35169204) (PMCID:PMC8847359)

Abstract

The aims of the current study, therefore, were to compare (1) free-living MPS and (2) muscle and metabolic adaptations to resistance exercise in South Asian and white European adults. Eighteen South Asian and 16 White European men were enrolled in the study. Free-living muscle protein synthesis was measured at baseline. Muscle strength, body composition, resting metabolic rate, VO2max and metabolic responses (insulin sensitivity) to a mixed meal were measured at baseline and following 12 weeks of resistance exercise training. Free-living muscle protein synthesis was not different between South Asians (1.48 ± 0.09%/day) and White Europeans (1.59 ± 0.15%/day) (p = 0.522). In response to resistance exercise training there were no differences, between South Asians and White Europeans, muscle mass, lower body strength or insulin sensitivity. However, there were differences between the ethnicities in response to resistance exercise training in body fat, resting carbohydrate and fat metabolism, blood pressure, VO2max and upper body strength with responses less favourable in South Asians. In this exploratory study there were no differences in muscle protein synthesis or anabolic and metabolic responses to resistance exercise, yet there were less favourable responses in several outcomes. These findings require further investigation.

• Item Type: Articles
• Additional Information: This research did not receive any specific grant. FA was supported by scholarship funding from the Saudi Government and AD was supported by scholarship funding from the Malaysian Government.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Welsh, Dr Paul and Celis, Dr Carlos and Gray, Professor Stuart and Johnston, Miss Lynsey and Sattar, Professor Naveed and Radjenovic, Dr Aleksandra and Preston, Professor Tom and Gill, Professor Jason and Wilson, John
• Authors: Aba Alkhayl, F. F., Ismail, A. D., Celis-Morales, C., Wilson, J., Radjenovic, A., Johnston, L., Welsh, P., Sattar, N., Gill, J. M.R., Preston, T., and Gray, S.
• College/School: College of Medical Veterinary and Life Sciences; College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Life Sciences; College of Science and Engineering > Scottish Universities Environmental Research Centre
• Journal Name: Scientific Reports
• Publisher: Nature Publishing Group
• ISSN: 2045-2322
• ISSN (Online): 2045-2322
• Copyright Holders: Copyright © The Author(s) 2022
• First Published: First published in Scientific Reports 12:2469
• Publisher Policy: Reproduced under a Creative Commons Licence