Vaccine effectiveness of heterologous CoronaVac plus BNT162b2 in Brazil

Cerqueira-Silva, T. et al. (2022) Vaccine effectiveness of heterologous CoronaVac plus BNT162b2 in Brazil. Nature Medicine, 28(4), pp. 838-843. (doi: 10.1038/s41591-022-01701-w) (PMID:35140406) (PMCID:PMC9018414)

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There is considerable interest in the waning of effectiveness of coronavirus disease 2019 (COVID-19) vaccines and vaccine effectiveness (VE) of booster doses. Using linked national Brazilian databases, we undertook a test-negative design study involving almost 14 million people (~16 million tests) to estimate VE of CoronaVac over time and VE of BNT162b2 booster vaccination against RT–PCR-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and severe COVID-19 outcomes (hospitalization or death). Compared with unvaccinated individuals, CoronaVac VE at 14–30 d after the second dose was 55.0% (95% confidence interval (CI): 54.3–55.7) against confirmed infection and 82.1% (95% CI: 81.4–82.8) against severe outcomes. VE decreased to 34.7% (95% CI: 33.1–36.2) against infection and 72.5% (95% CI: 70.9–74.0) against severe outcomes over 180 d after the second dose. A BNT162b2 booster, 6 months after the second dose of CoronaVac, improved VE against infection to 92.7% (95% CI: 91.0−94.0) and VE against severe outcomes to 97.3% (95% CI: 96.1−98.1) 14–30 d after the booster. Compared with younger age groups, individuals 80 years of age or older had lower protection after the second dose but similar protection after the booster. Our findings support a BNT162b2 booster vaccine dose after two doses of CoronaVac, particularly for the elderly.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Katikireddi, Professor Vittal
Authors: Cerqueira-Silva, T., Katikireddi, S. V., de Araujo Oliveira, V., Flores-Ortiz, R., Júnior, J. B., Paixão, E. S., Robertson, C., Penna, G. O., Werneck, G. L., Barreto, M. L., Pearce, N., Sheikh, A., Barral-Netto, M., and Boaventura, V. S.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
Journal Name:Nature Medicine
Publisher:Nature Research
ISSN (Online):1546-170X
Published Online:09 February 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Nature Medicine 28(4): 838-843
Publisher Policy:Reproduced under a Creative Commons licence

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
3048230021Inequalities in healthAlastair LeylandMedical Research Council (MRC)MC_UU_00022/2HW - MRC/CSO Social and Public Health Sciences Unit
3048230071Inequalities in healthAlastair LeylandOffice of the Chief Scientific Adviser (CSO)SPHSU17HW - MRC/CSO Social and Public Health Sciences Unit
172690Understanding the impacts of welfare policy on health: A novel data linkage studySrinivasa KatikireddiOffice of the Chief Scientific Adviser (CSO)SCAF/15/02SHW - Public Health
300390Strengthening data linkage to reduce health inequalities in low and middle income countries: building on the Brazilian 100 million cohortAlastair LeylandNational Institute for Health Research (NIHR)16/137/99SHW - MRC/CSO Social & Public Health Sciences Unit