Risk factors associated with short‐term mortality and recurrence of status epilepticus in dogs

Fentem, R., de Stefani, A., Gutierrez Quintana, R. , Alcoverro, E., Jones, G. M. C., Amengual-Batle, P. and Gonçalves, R. (2022) Risk factors associated with short‐term mortality and recurrence of status epilepticus in dogs. Journal of Veterinary Internal Medicine, 36(2), pp. 656-662. (doi: 10.1111/jvim.16353) (PMID:34994484) (PMCID:PMC8965210)

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Abstract

Background: Status epilepticus (SE) is an emergency associated with serious consequences for both patient and owner. Data regarding risk factors for short-term mortality or recurrence in dogs with SE is limited. Objective: Identify risk factors associated with short-term mortality (euthanasia or spontaneous death) and recurrence of SE in dogs. Animals: One hundred twenty-four client-owned dogs that sustained an episode of SE. Methods: Retrospective multicenter study using data collected from medical records of dogs presented in SE to the contributing institutions. Multivariable logistic regression analysis was performed using a manual backwards stepwise approach to identify risk factors associated with short-term mortality and recurrence of SE after discharge. Results: Short-term mortality for affected dogs was 29.8%. Factors significantly associated with short-term mortality included increased patient age, shorter duration of hospitalization, development of SE before arrival, and SE caused by a potentially fatal etiology. Status epilepticus recurred in 27% of dogs that survived to discharge. Factors significantly associated with recurrence of SE included prior history of pharmacoresistant epilepsy and predominance of a focal seizure phenotype. Conclusions and Clinical Importance: Our results may be used to inform clinicians and dog owners regarding risk factors for both short-term mortality and recurrence in dogs with SE.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Amengual Batle, Pablo and Gutierrez Quintana, Mr Rodrigo
Authors: Fentem, R., de Stefani, A., Gutierrez Quintana, R., Alcoverro, E., Jones, G. M. C., Amengual-Batle, P., and Gonçalves, R.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Journal of Veterinary Internal Medicine
Publisher:Wiley
ISSN:0891-6640
ISSN (Online):1939-1676
Published Online:07 January 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Journal of Veterinary Internal Medicine 36(2): 656-662
Publisher Policy:Reproduced under a Creative Commons Licence

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