The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysis

Mazidi, M., Dehghan, A., Mikhailidis, D., Jóźwiak, J., Covic, A., Sattar, N. , Banach, M., on behalf of the Lipid and Blood Pressure Meta-analysis Collab, and the International Lipid Expert Panel (ILEP), (2022) The association between coffee and caffeine consumption and renal function: insight from individual-level data, Mendelian randomization, and meta-analysis. Archives of Medical Science, 18(4), pp. 900-911. (doi: 10.5114/aoms/144905) (PMID:35832703) (PMCID:PMC9266873)

Abstract

Introduction: By applying on two-sample Mendelian randomization and systematic review and meta-analysis we investigated the association between caffeine and coffee intake with prevalent CKD and markers of renal function. Material and methods: For the individual data analysis we analysed the NHANES data on renal function markers and caffeine intake. MR was implemented by using summary-level data from the largest ever GWAS conducted on coffee intake (N=91,462) and kidney function. Results: Finally, we included the data of 18,436 participants, 6.9% had prevalent CKD (based on eGFR). Caffeine intake for general population was 131.1±1.1 mg. The percentage of participants with CKD, by caffeine quartile was 16.6% in the first (lowest) quartile, 13.9% in the second, 12.2% in the third and 11.0% in the top quartile (p<0.001). After adjustment, for increasing quartiles for caffeine consumption, mean urine albumin, albumin-creatinine ratio and estimated glomerular filtration rate (GFR) did not change significantly (p>0.234). In fully adjusted logistic regression models, there was no significant difference in chances of CKD prevalence (p-trend=0.745). In the same line, results of MR showed no impact of coffee intake on CKD (IVW=β: -0.0191, SE: 0.069, p=0.781), on eGFR (overall= IVW= β: -0.0005, SE: 0.005, p=0.926) both in diabetic (IVW= β: -0.006, SE: 0.009, p=0.478), and non-diabetic patients (IVW= β: -6.772, SE: 0.006, p=0.991). Results from the meta-analysis indicted that coffee consumption was not significantly associated with CKD (OR: 0.85, 95%CI 0.71-1.02, p=0.090, n=6 studies, I2=0.32). Conclusions: By implementing on different strategies, we have highlighted no significant association between coffee consumption with renal function and chance of CKD.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Sattar, Professor Naveed
• Authors: Mazidi, M., Dehghan, A., Mikhailidis, D., Jóźwiak, J., Covic, A., Sattar, N., Banach, M., on behalf of the Lipid and Blood Pressure Meta-analysis Collab, , and the International Lipid Expert Panel (ILEP),
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Archives of Medical Science
• Publisher: Termedia
• ISSN: 1734-1922
• ISSN (Online): 1896-9151
• Published Online: 14 December 2021
• Copyright Holders: Copyright © 2021 Termedia and Banach
• First Published: First published in Archives of Medical Science 18(4): 900-911
• Publisher Policy: Reproduced under a Creative Commons License