Dissociation and brain rhythms: pitfalls and promises

Grent-'t-Jong, T. , Melloni, L. and Uhlhaas, P. J. (2021) Dissociation and brain rhythms: pitfalls and promises. Frontiers in Psychiatry, 12, 790372. (doi: 10.3389/fpsyt.2021.790372)

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Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhythm that underlies states of dissociation. In the following, we would like to critically review these findings in the context of the human literature on dissociation as well as highlight the challenges in translational neuroscience to link complex behavioral phenotypes in psychiatric syndromes to circumscribed circuit mechanisms.

Item Type:Articles
Keywords:Dissociation, ketamine, neural oscillations, optogenetics, animal models, translational neuroscience.
Glasgow Author(s) Enlighten ID:Uhlhaas, Professor Peter and Grent-'T-Jong, Dr Tineke
Authors: Grent-'t-Jong, T., Melloni, L., and Uhlhaas, P. J.
College/School:College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
Journal Name:Frontiers in Psychiatry
Publisher:Frontiers Media
ISSN (Online):1664-0640
Copyright Holders:Copyright © 2021 Grent-’t-Jong, Melloni and Uhlhaas
First Published:First published in Frontiers in Psychiatry 12: 790372
Publisher Policy:Reproduced under a Creative Commons License

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