Dissociation and brain rhythms: pitfalls and promises

Grent-'t-Jong, T. , Melloni, L. and Uhlhaas, P. J. (2021) Dissociation and brain rhythms: pitfalls and promises. Frontiers in Psychiatry, 12, 790372. (doi: 10.3389/fpsyt.2021.790372)

Abstract

Recently, Vesuna et al. proposed a novel circuit mechanism underlying dissociative states using optogenetics and pharmacology in mice in combination with intracranial recordings and electrical stimulation in an epilepsy patient. Specifically, the authors identified a posteromedial cortical delta-rhythm that underlies states of dissociation. In the following, we would like to critically review these findings in the context of the human literature on dissociation as well as highlight the challenges in translational neuroscience to link complex behavioral phenotypes in psychiatric syndromes to circumscribed circuit mechanisms.

• Item Type: Articles
• Keywords: Dissociation, ketamine, neural oscillations, optogenetics, animal models, translational neuroscience.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Uhlhaas, Professor Peter and Grent-'T-Jong, Dr Tineke
• Authors: Grent-'t-Jong, T., Melloni, L., and Uhlhaas, P. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience
• Journal Name: Frontiers in Psychiatry
• Publisher: Frontiers Media
• ISSN: 1664-0640
• ISSN (Online): 1664-0640
• Copyright Holders: Copyright © 2021 Grent-’t-Jong, Melloni and Uhlhaas
• First Published: First published in Frontiers in Psychiatry 12: 790372
• Publisher Policy: Reproduced under a Creative Commons License