Christ Cédras Capo-Chichi, J., Alvarenga Borges, N., Cristhiny Mendes de Vargas Reis, D., Nakao, L. S. and Mafra, D. (2022) Is there an association between the plasma levels of uremic toxins from gut microbiota and anemia in patients on hemodialysis? International Urology and Nephrology, 54(6), pp. 1271-1277. (doi: 10.1007/s11255-021-03001-7) (PMID:34561817)
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Abstract
Background: Anemia is one of the most frequent complications in patients with chronic kidney disease (CKD). Despite being multifactorial, the relative or absolute deficiency of erythropoietin production is the leading cause. Recent studies have shown that uremic toxins produced by the gut microbiota also may play a role in the genesis of anemia in these patients. Objective: To evaluate the possible association between uremic toxins plasma levels and anemia in patients with CKD on hemodialysis (HD). Methods: This cross-sectional study evaluated one hundred fifty-four patients (53.2% men, 51.2 ± 11.2 years, hemoglobin (Hb) levels of 11.2 ± 1.6 g/dL). Biochemical variables such as urea, creatinine, hemoglobin, hematocrit, were measured according to standard methods and uremic toxins such as indoxyl sulfate (IS), indole-3-acetic acid (IAA), p-cresyl sulfate (p-CS) plasma levels were measured by reverse-phase high-performance liquid chromatography (RP-HPLC). Results: The levels of uremic toxins such as IS, IAA, p-CS were increased in all patients. However, no correlation was found between uremic toxins plasma levels and anemia parameters. Only patients with Hb < 11 g/dL presented a negative correlation between hematocrit and IAA plasma levels. Conclusion: There is no strong evidence that uremic toxins produced by the gut microbiota may be associated with anemia in patients with CKD on HD.
| Item Type: | Articles |
|---|---|
| Additional Information: | Funding: Conselho Nacional de Pesquisa (CNPq) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) support Denise Mafra research. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Mafra, Prof Denise |
| Authors: | Christ Cédras Capo-Chichi, J., Alvarenga Borges, N., Cristhiny Mendes de Vargas Reis, D., Nakao, L. S., and Mafra, D. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | International Urology and Nephrology |
| Publisher: | Springer |
| ISSN: | 0301-1623 |
| ISSN (Online): | 1573-2584 |
| Published Online: | 24 September 2021 |
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