Quality of life from cytoreductive surgery in advanced Ovarian cancer: investigating association with disease burden and surgical complexity in the international, prospective, SOCQER2 cohort study

Sundar, S. et al. (2022) Quality of life from cytoreductive surgery in advanced Ovarian cancer: investigating association with disease burden and surgical complexity in the international, prospective, SOCQER2 cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 129(7), pp. 1122-1132. (doi: 10.1111/1471-0528.17041) (PMID:34865316)

Abstract

Objective: To investigate quality of life (QoL) and association with surgical complexity and disease burden after surgical resection for advanced ovarian cancer in centres with variation in surgical approach Design: Prospective multicentre observational study Setting: United Kingdom, Kolkata, India, and Melbourne, Australia gynaecological cancer surgery centres. Participants: Patients undergoing surgical resection for late stage ovarian cancer. Exposure Low, intermediate or high Surgical Complexity Score (SCS) surgery Main outcomes and measures: Primary: EORTC-QLQ-C30 Global score change. Secondary: EORTC OV28, progression free survival. Results: Patients’ pre-operative disease burden and SCS varied between centres, confirming differences in surgical ethos. QoL response rates were 90% up to 18 months. Mean change from the pre-surgical baseline in the EORTC QLQ-C30 was 3.4 (SD 1.8, n=88) in the low, 4.0 (SD 2.1, n=55) in the intermediate and 4.3 (SD 2.1, n=52) in the high SCS group after 6 weeks (p=0.048) and 4.3 (SD 2.1, n=51), 5.1 (SD 2.2, n=41) and 5.1 (SD 2.2, n=35) respectively after 12 months (p=0.133). In a repeated measures model, there were no clinically or statistically meaningful differences in EORTC QLQ-C30 global scores between the three SCS groups, p= 0.840 but there was a small statistically significant improvement in all groups over time (p<0.001). The high SCS group experienced small to moderate decreases in physical (p=0.004), role (p=0.016) and emotional (p=0.001) function at 6 weeks post-surgery which resolved by 6-12 months. Conclusions and relevance: Global QoL of patients undergoing low, intermediate, and high SCS surgery improved at 12 months post operation and was no worse in patients undergoing extensive surgery.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Glasspool, Dr Rosalind
• Authors: Sundar, S., Cummins, C., Kumar, S., Long, J., Arora, V., Balega, J., Broadhead, T., Duncan, T., Edmondson, R., Fotopoulou, C., Glasspool, R., Kolomainen, D., Leeson, S., Manchanda, R., McNally, O., Morrison, J., Mukhopadhyay, A., Paul, J., Tidy, J., and Wood, N.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: BJOG: An International Journal of Obstetrics and Gynaecology
• Publisher: Wiley
• ISSN: 1470-0328
• ISSN (Online): 1471-0528
• Published Online: 05 December 2021
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in BJOG: An International Journal of Obstetrics and Gynaecology 129(7): 1122-1132
• Publisher Policy: Reproduced under a Creative Commons License