Serotype replacement after introduction of 10-valent and 13-valent pneumococcal conjugate vaccines in 10 countries, Europe

Hanquet, G. et al. (2022) Serotype replacement after introduction of 10-valent and 13-valent pneumococcal conjugate vaccines in 10 countries, Europe. Emerging Infectious Diseases, 28(1), pp. 127-138. (doi: 10.3201/eid2801.210734) (PMID:34932457) (PMCID:PMC8714201)

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We evaluated invasive pneumococcal disease (IPD) during 8 years of infant pneumococcal conjugate vaccine (PCV) programs using 10-valent (PCV10) and 13-valent (PCV13) vaccines in 10 countries in Europe. IPD incidence declined during 2011–2014 but increased during 2015–2018 in all age groups. From the 7-valent PCV period to 2018, IPD incidence declined by 42% in children <5 years of age, 32% in persons 5–64 years of age, and 7% in persons >65 years of age; non-PCV13 serotype incidence increased by 111%, 63%, and 84%, respectively, for these groups. Trends were similar in countries using PCV13 or PCV10, despite different serotype distribution. In 2018, serotypes in the 15-valent and 20-valent PCVs represented one third of cases in children <5 years of age and two thirds of cases in persons >65 years of age. Non-PCV13 serotype increases reduced the overall effect of childhood PCV10/PCV13 programs on IPD. New vaccines providing broader serotype protection are needed.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Smith, Professor Andrew
Authors: Hanquet, G., Krizova, P., Dalby, T., Ladhani, S. N., Nuorti, J. P., Danis, K., Mereckiene, J., Knol, M. J., Winje, B. A., Ciruela, P., de Miguel, S., Portillo, M. E., MacDonald, L., Morfeldt, E., Kozakova, J., Valentiner-Branth, P., Fry, N. K., Rinta-Kokko, H., Varon, E., Corcoran, M., van der Ende, A., Vestrheim, D. F., Munoz-Almagro, C., Sanz, J.-C., Castilla, J., Smith, A., Henriques-Normark, B., Colzani, E., Pastore-Celentano, L., and Savulescu, C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Emerging Infectious Diseases
Publisher:Centers for Disease Control and Prevention
ISSN (Online):1080-6059
Published Online:08 December 2021
Copyright Holders:Materials published in Emerging Infectious Diseases, including text, figures, tables, and photographs are in the public domain and can be reprinted or used without permission with proper citation.
First Published:First published in Emerging Infectious Diseases 28(1):127-138
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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