Verdonschot, J. A.J. et al. (2022) The effect of spironolactone in patients with obesity at risk for heart failure: proteomic insights from the HOMAGE trial. Journal of Cardiac Failure, 28(5), pp. 778-786. (doi: 10.1016/j.cardfail.2021.12.005) (PMID:34933097)
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Abstract
Background: Adipose tissue influences the expression and degradation of circulating biomarkers. We aimed to identify the biomarker profile and biological meaning of biomarkers associated with obesity to assess the effect of spironolactone on the circulating biomarkers and to explore whether obesity might modify the effect of spironolactone. Methods and Results: Protein biomarkers (n = 276) from the Olink Proseek–Multiplex cardiovascular and inflammation panels were measured in plasma collected at baseline, 1 month and 9 months from the HOMAGE randomized controlled trial participants. Of the 510 participants, 299 had obesity defined as an increased waist circumference (≥102 cm in men and ≥88 cm in women). Biomarkers at baseline reflected adipogenesis, increased vascularization, decreased fibrinolysis, and glucose intolerance in patients with obesity at baseline. Treatment with spironolactone had only minor effects on this proteomic profile. Obesity modified the effect of spironolactone on systolic blood pressure (Pinteraction = 0.001), showing a stronger decrease of blood pressure in obese patients (–14.8 mm Hg 95% confidence interval –18.45 to –11.12) compared with nonobese patients (–3.6 mm Hg 95% confidence interval –7.82 to 0.66). Conclusions: Among patients at risk for heart failure, those with obesity have a characteristic proteomic profile reflecting adipogenesis and glucose intolerance. Spironolactone had only minor effects on this obesity-related proteomic profile, but obesity significantly modified the effect of spironolactone on systolic blood pressure.
Item Type: | Articles |
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Additional Information: | The research leading to these results has received funding from the European Union Commission's Seventh Framework programme under grant agreement N° 305507 (HOMAGE). S.H.: This manuscript has been possible thanks to the support of the Netherlands Cardiovascular Research Initiative, an initiative with support of the Dutch Heart Foundation, CVON2016-Early HFPEF, 2015-10, CVON She-PREDICTS, grant 2017-21. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Cleland, Professor John and Ferreira, Mr Joao Pedro and Pellicori, Dr Pierpaolo |
Authors: | Verdonschot, J. A.J., Ferreira, J. P., Pizard, A., Pellicori, P., Brunner La Rocca, H.-P., Clark, A. L., Cosmi, F., Cuthbert, J., Girerd, N., Waring, O. J., Henkens, M. H.T.M., Mariottoni, B., Petutschnigg, J., Rossignol, P., Hazebroek, M. R., Cleland, J. G.F., Zannad, F., and Heymans, S. R.B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Robertson Centre |
Journal Name: | Journal of Cardiac Failure |
Publisher: | Elsevier |
ISSN: | 1071-9164 |
ISSN (Online): | 1532-8414 |
Published Online: | 18 December 2021 |
Copyright Holders: | Copyright © 2021 The Authors |
First Published: | First published in Journal of Cardiac Failure 28(5): 778-786 |
Publisher Policy: | Reproduced under a Creative Commons License |
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