Deconstructing pancreatic cancer using next generation-omic technologies–from discovery to knowledge-guided platforms for better patient management

Schreyer, D., Neoptolemos, J. P., Barry, S. T. and Bailey, P. J. (2022) Deconstructing pancreatic cancer using next generation-omic technologies–from discovery to knowledge-guided platforms for better patient management. Frontiers in Cell and Developmental Biology, 9, 795735. (doi: 10.3389/fcell.2021.795735) (PMID:35096825) (PMCID:PMC8793685)

Abstract

Comprehensive molecular landscaping studies reveal a potentially brighter future for pancreatic ductal adenocarcinoma (PDAC) patients. Blood-borne biomarkers obtained from minimally invasive “liquid biopsies” are now being trialled for early disease detection and to track responses to therapy. Integrated genomic and transcriptomic studies using resectable tumour material have defined intrinsic patient subtypes and actionable genomic segments that promise a shift towards genome-guided patient management. Multimodal mapping of PDAC using spatially resolved single cell transcriptomics and imaging techniques has identified new potentially therapeutically actionable cellular targets and is providing new insights into PDAC tumour heterogeneity. Despite these rapid advances, defining biomarkers for patient selection remain limited. This review examines the current PDAC cancer biomarker ecosystem (identified in tumour and blood) and explores how advances in single cell sequencing and spatially resolved imaging modalities are being used to uncover new targets for therapeutic intervention and are transforming our understanding of this difficult to treat disease.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Schreyer, Mr Daniel and Bailey, Dr Peter
• Authors: Schreyer, D., Neoptolemos, J. P., Barry, S. T., and Bailey, P. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Frontiers in Cell and Developmental Biology
• Publisher: Frontiers Media
• ISSN: 2296-634X
• ISSN (Online): 2296-634X
• Copyright Holders: Copyright © 2022 Schreyer, Neoptolemos, Barry and Bailey
• First Published: First published in Frontiers in Cell and Developmental Biology 9: 795735
• Publisher Policy: Reproduced under a Creative Commons License

Project Code	Award No	Project Name	Principal Investigator	Funder's Name	Funder Ref	Lead Dept
306698		PancREatic Cancer OrganoiDs rEsearch Network	Peter Bailey	European Commission (EC)	861196	CS -Translational Research Centre