Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer

Michie, A. M. , McCaig, A. M., Nakagawa, R. and Vukovic, M. (2010) Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer. FEBS Journal, 277(1), pp. 74-80. (doi: 10.1111/j.1742-4658.2009.07414.x)

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Death-associated protein kinase (DAPK) is a pro-apoptotic serine/threonine protein kinase that is dysregulated in a wide variety of cancers. The mechanism by which this occurs has largely been attributed to promoter hypermethylation, which results in gene silencing. However, recent studies indicate that DAPK expression can be detected in some cancers, but its function is still repressed, suggesting that DAPK activity can be subverted at a post-translational level in cancer cells. This review will focus on recent data describing potential mechanisms that may alter the expression, regulation or function of DAPK.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Michie, Professor Alison and Mccaig, Dr Alison and Vukovic, Ms Milica and Nakagawa, Dr Rinako
Authors: Michie, A. M., McCaig, A. M., Nakagawa, R., and Vukovic, M.
College/School:College of Medical Veterinary and Life Sciences > School of Cancer Sciences
Journal Name:FEBS Journal
Publisher:Wiley-Blackwell Publishing
ISSN (Online):1742-4658
Published Online:30 October 2009
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
444831Defining the cellular origin of chronic lymphocytic leukaemiaAlison MichieMedical Research Council (MRC)G0601099Institute of Cancer Sciences