Michie, A. M. , McCaig, A. M., Nakagawa, R. and Vukovic, M. (2010) Death-associated protein kinase (DAPK) and signal transduction: regulation in cancer. FEBS Journal, 277(1), pp. 74-80. (doi: 10.1111/j.1742-4658.2009.07414.x)
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Publisher's URL: http://dx.doi.org/10.1111/j.1742-4658.2009.07414.x
Abstract
Death-associated protein kinase (DAPK) is a pro-apoptotic serine/threonine protein kinase that is dysregulated in a wide variety of cancers. The mechanism by which this occurs has largely been attributed to promoter hypermethylation, which results in gene silencing. However, recent studies indicate that DAPK expression can be detected in some cancers, but its function is still repressed, suggesting that DAPK activity can be subverted at a post-translational level in cancer cells. This review will focus on recent data describing potential mechanisms that may alter the expression, regulation or function of DAPK.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Michie, Professor Alison and Mccaig, Dr Alison and Vukovic, Ms Milica and Nakagawa, Dr Rinako |
| Authors: | Michie, A. M., McCaig, A. M., Nakagawa, R., and Vukovic, M. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | FEBS Journal |
| Publisher: | Wiley-Blackwell Publishing |
| ISSN: | 1742-464X |
| ISSN (Online): | 1742-4658 |
| Published Online: | 30 October 2009 |
| Related URLs: |
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