Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia (Protocol)

Taylor-Rowan, M. , Kraia, O., Kolliopoulou, C., Cross, A. J., Stewart, C., Myint, P. K., McCleery, J. and Quinn, T. J. (2021) Anticholinergic burden for prediction of cognitive decline or neuropsychiatric symptoms in older adults with mild cognitive impairment or dementia (Protocol). Cochrane Database of Systematic Reviews, 2021(11), CD015196. (doi: 10.1002/14651858.cd015196) (PMCID:PMC8601112)

Abstract

Objectives: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows: Primary objective: To assess whether anticholinergic burden, as defined at the level of each individual scale, is a prognostic factor for further cognitive decline or neuropsychiatric disturbances in people with mild cognitive impairment (MCI) or dementia. Secondary objective: To compare the prognostic validity of different anticholinergic burden scales. To examine the effect of type of dementia and severity of dementia on the association between anticholinergic burden and rate of cognitive decline or neuropsychiatric disturbances. To examine the effect of setting (care home versus non‐care home) on the association between anticholinergic burden and rate of cognitive decline or neuropsychiatric disturbances. To examine whether anticholinergic burden is a prognostic factor for other clinical outcomes in people with MCI or dementia

• Item Type: Articles
• Additional Information: This protocol was supported by the National Institute for Health Research (NIHR), via Cochrane Infrastructure funding to the Cochrane Dementia and Cognitive Improvement group.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Quinn, Professor Terry and Taylor-Rowan, Dr Martin
• Authors: Taylor-Rowan, M., Kraia, O., Kolliopoulou, C., Cross, A. J., Stewart, C., Myint, P. K., McCleery, J., and Quinn, T. J.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health; College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > General Practice and Primary Care
• Journal Name: Cochrane Database of Systematic Reviews
• Publisher: Cochrane Collaboration
• ISSN: 1469-493X
• ISSN (Online): 1469-493X
• Copyright Holders: Copyright © 2021 The Cochrane Collaboration
• First Published: First published in Cochrane Database of Systematic Reviews 2021(11):CD015196
• Publisher Policy: Reproduced in accordance with the publisher copyright policy