Nicotinic I-123-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in alzheimer's disease and dementia with Lewy bodies

Colloby, S.J., Perry, E.K., Pakrasi, S., Pimlott, S.L., Wyper, D.J., McKeith, I.G., Williams, E.D. and O'Brien, J.T. (2010) Nicotinic I-123-5IA-85380 single photon emission computed tomography as a predictor of cognitive progression in alzheimer's disease and dementia with Lewy bodies. American Journal of Geriatric Psychiatry, 18(1), pp. 86-90. (doi: 10.1097/JGP.0b013e3181b972aa)

Abstract

Objective: To investigate normalized ¹²³I-5-Iodo-3-[2(S)-2-azetidinylmethoxy] pyridine (5IA-85380) single photon emission computed tomography (SPECT) imaging, a marker for the α4β2 nicotinic receptor, as a predictor of cognitive progression in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Methods: Thirty-one patients with dementia (16 patients with AD and 15 patients with DLB) underwent ¹²³I-5IA-85380 SPECT scanning. Image analysis was performed using statistical parametric mapping (SPM2), which involved spatial preprocessing of scans to standard Montreal Neurological Institute space and intensity normalization of each image to its mean global brain activity. Results: Regression analysis revealed that reduced normalized ¹²³I-5IA-85380 uptake in left superior, middle, and inferior frontal gyri and prepost central and anterior cingulate regions significantly correlated with decline in executive function in a pooled group comprising AD and DLB. Conclusion: The findings, although preliminary, suggest that the cholinergic system may be more involved in neurodegenerative processes affecting some cognitive processes more than others, as such, this procedure may be useful for increased understanding of the pathophysiological mechanisms responsible for neurodegeneration.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Wyper, Professor David and Pimlott, Dr Sally
• Authors: Colloby, S.J., Perry, E.K., Pakrasi, S., Pimlott, S.L., Wyper, D.J., McKeith, I.G., Williams, E.D., and O'Brien, J.T.
• Subjects: R Medicine > R Medicine (General)
• College/School: College of Medical Veterinary and Life Sciences
• Journal Name: American Journal of Geriatric Psychiatry
• ISSN: 1064-7481
• ISSN (Online): 1545-7214