Kluger, D. S. and Gross, J. (2021) Respiration modulates oscillatory neural network activity at rest. PLoS Biology, 19(11), e3001457. (doi: 10.1371/journal.pbio.3001457)
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Abstract
Despite recent advances in understanding how respiration affects neural signalling to influence perception, cognition, and behaviour, it is yet unclear to what extent breathing modulates brain oscillations at rest. We acquired respiration and resting state magnetoencephalography (MEG) data from human participants to investigate if, where, and how respiration cyclically modulates oscillatory amplitudes (2 to 150 Hz). Using measures of phase–amplitude coupling, we show respiration-modulated brain oscillations (RMBOs) across all major frequency bands. Sources of these modulations spanned a widespread network of cortical and subcortical brain areas with distinct spectrotemporal modulation profiles. Globally, delta and gamma band modulations varied with distance to the head centre, with stronger modulations at distal (versus central) cortical sites. Overall, we provide the first comprehensive mapping of RMBOs across the entire brain, highlighting respiration–brain coupling as a fundamental mechanism to shape neural processing within canonical resting state and respiratory control networks (RCNs).
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by the Interdisciplinary Center for Clinical Research (IZKF) of the medical faculty of Muenster, Grant Number Gro3/001/19 (JG) and the German Research Foundation, Grant Number GR 2024/5-1 (JG). |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Gross, Professor Joachim |
| Creator Roles: | Gross, J.Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review and editing |
| Authors: | Kluger, D. S., and Gross, J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Psychology & Neuroscience |
| Journal Name: | PLoS Biology |
| Publisher: | Public Library of Science |
| ISSN: | 1544-9173 |
| ISSN (Online): | 1545-7885 |
| Published Online: | 11 November 2021 |
| Copyright Holders: | Copyright © 2021 Kluger, Gross |
| First Published: | First published in PLoS Biology 19(11): e3001457 |
| Publisher Policy: | Reproduced under a Creative Commons License |
| Related URLs: |
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