Comparison of response assessment in veterinary neuro‐oncology and two volumetric neuroimaging methods to assess therapeutic brain tumour responses in veterinary patients

Coppola, G., Morris, J. , Gutierrez-Quintana, R. , Burnside, S. and Jose-Lopez, R. (2022) Comparison of response assessment in veterinary neuro‐oncology and two volumetric neuroimaging methods to assess therapeutic brain tumour responses in veterinary patients. Veterinary and Comparative Oncology, 20(2), pp. 404-415. (doi: 10.1111/vco.12786)

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Abstract

Standardized veterinary neuroimaging response assessment methods for brain tumours are lacking. Consequently, a response assessment in veterinary neuro-oncology (RAVNO) system which uses the sum product of orthogonal lesion diameters on 1-image section with the largest tumour area, has recently been proposed. In this retrospective study, 22 pre-treatment magnetic resonance imaging (MRI) studies from 18 dogs and four cats with suspected intracranial neoplasia were compared by a single observer to 32 post-treatment MRIs using the RAVNO system and two volumetric methods based on tumour margin or area delineation with HOROS and 3D Slicer software, respectively. Intra-observer variability was low, with no statistically significant differences in agreement index between methods (mean AI ± SD, 0.91 ± 0.06 for RAVNO; 0.86 ± 0.08 for HOROS; and 0.91 ± 0.05 for 3D slicer), indicating good reproducibility. Response assessments consisting of complete or partial responses, and stable or progressive disease, agreed in 23 out of 32 (72%) MRI evaluations using the three methods. The RAVNO system failed to identify changes in mass burden detected with volumetric methods in six cases. 3D Slicer differed from the other two methods in three cases involving cysts or necrotic tissue as it allowed for more accurate exclusion of these structures. The volumetric response assessment methods were more precise in determining changes in absolute tumour burden than RAVNO but were more time-consuming to use. Based on observed agreement between methods, low intra-observer variability and decreased time constraint, RAVNO might be a suitable response assessment method for the clinical setting.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coppola, Giovanni and Burnside, Miss Shona and Morris, Professor Joanna and Jose-Lopez, Mr Roberto and Gutierrez Quintana, Mr Rodrigo
Authors: Coppola, G., Morris, J., Gutierrez-Quintana, R., Burnside, S., and Jose-Lopez, R.
College/School:College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine
Journal Name:Veterinary and Comparative Oncology
Publisher:Wiley
ISSN:1476-5810
ISSN (Online):1476-5829
Published Online:18 November 2021
Copyright Holders:Copyright © 2021 John Wiley and Sons Ltd.
First Published:First published in Veterinary and Comparative Oncology 20(2): 404-415
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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