Predicting cardiovascular stent complications using self-reporting biosensors for noninvasive detection of disease

Hoare, D. et al. (2022) Predicting cardiovascular stent complications using self-reporting biosensors for noninvasive detection of disease. Advanced Science, 9(15), 2105285. (doi: 10.1002/advs.202105285) (PMID:35322587) (PMCID:PMC9130883)

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Abstract

Self-reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re-block after deployment due to a wound response called in-stent restenosis (ISR). Herein, an implantable miniaturized sensor and telemetry system are developed that can detect this process, discern the different cell types associated with ISR, distinguish sub plaque components as demonstrated with ex vivo samples, and differentiate blood from blood clot, all on a silicon substrate making it suitable for integration onto a vascular stent. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Holsgrove, Mr Michael and Hoare, Mr Daniel and Neale, Dr Steven and Czyzewski, Mr Jakub and Mercer, Dr John and Kirimi, Mahmut Talha and Mirzai, Mr Nosrat and Mitra, Dr Srinjoy and Russell, Mr Ewan
Authors: Hoare, D., Tsiamis, A., Marland, J. R.K., Czyzewski, J., Kirimi, M. T., Holsgrove, M., Russell, E., Neale, S. L., Mirzai, N., Mitra, S., and Mercer, J. R.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Science and Engineering > School of Engineering > Systems Power and Energy
Journal Name:Advanced Science
Publisher:Wiley
ISSN:2198-3844
ISSN (Online):2198-3844
Published Online:24 March 2022
Copyright Holders:Copyright © 2022 The Authors
First Published:First published in Advanced Science 9(15): 2105285
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
190814BHF centre of excellenceRhian TouyzBritish Heart Foundation (BHF)RE/13/5/30177Institute of Cardiovascular & Medical Sciences
304979University of Glasgow NPIF 2018Heather LambieEngineering and Physical Sciences Research Council (EPSRC)EP/S515401/1S&E - Graduate School
301576ISFC Wave 1: High Energy Density Capacitors Manufactured with Optoelectronic Tweezers (CapOET)Steven NealeEngineering and Physical Sciences Research Council (EPSRC)EP/R020892/1ENG - Systems Power & Energy
301336Design and fabrication of a remote controlled wireless impedance sensing unit for a new cardiovascular medical device.John MercerOffice of the Chief Scientific Adviser (CSO)CGA/17/29CAMS - Cardiovascular Science
308165Institutional Translation Partnership AwardGerard GrahamWellcome Trust (WELLCOTR)219390/Z/19/ZMVLS - College Senior Management