Hoare, D. et al. (2022) Predicting cardiovascular stent complications using self-reporting biosensors for noninvasive detection of disease. Advanced Science, 9(15), 2105285. (doi: 10.1002/advs.202105285) (PMID:35322587) (PMCID:PMC9130883)
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Abstract
Self-reporting implantable medical devices are the future of cardiovascular healthcare. Cardiovascular complications such as blocked arteries that lead to the majority of heart attacks and strokes are frequently treated with inert metal stents that reopen affected vessels. Stents frequently re-block after deployment due to a wound response called in-stent restenosis (ISR). Herein, an implantable miniaturized sensor and telemetry system are developed that can detect this process, discern the different cell types associated with ISR, distinguish sub plaque components as demonstrated with ex vivo samples, and differentiate blood from blood clot, all on a silicon substrate making it suitable for integration onto a vascular stent. This work shows that microfabricated sensors can provide clinically relevant information in settings closer to physiological conditions than previous work with cultured cells.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Holsgrove, Mr Michael and Hoare, Dr Daniel and Neale, Professor Steven and Czyzewski, Mr Jakub and Mercer, Dr John and Kirimi, Mahmut Talha and Mirzai, Mr Nosrat and Mitra, Dr Srinjoy and Russell, Mr Ewan |
| Authors: | Hoare, D., Tsiamis, A., Marland, J. R.K., Czyzewski, J., Kirimi, M. T., Holsgrove, M., Russell, E., Neale, S. L., Mirzai, N., Mitra, S., and Mercer, J. R. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Science and Engineering > School of Engineering > Systems Power and Energy |
| Journal Name: | Advanced Science |
| Publisher: | Wiley |
| ISSN: | 2198-3844 |
| ISSN (Online): | 2198-3844 |
| Published Online: | 24 March 2022 |
| Copyright Holders: | Copyright © 2022 The Authors |
| First Published: | First published in Advanced Science 9(15): 2105285 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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