SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the α4β2 nicotinic acetylcholine receptor [123I]5-I-A85380 ligand: In vivo and in vitro evidence

Cavanagh, J. , Patterson, J., Pimlott, S. , Wyper, D. and Dewar, D. (2010) SSRI antidepressants do not confound single photon emission computed tomography (SPECT) imaging studies using the α4β2 nicotinic acetylcholine receptor [123I]5-I-A85380 ligand: In vivo and in vitro evidence. Synapse, 64(2), pp. 111-116. (doi: 10.1002/syn.20705) (PMID:19771591)

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Abstract

Purpose: In clinical molecular imaging the interaction between antidepressant medication and SPECT ligands is a significant potential confound. This study measured nAChR availability, as determined by SPECT imaging, on and off selective serotonin reuptake inhibitors in first episode depressed patients. Methods: Five patients in their first episode of major depressive disorder (MDD) on a single SSRI underwent [123I]5-I-A85380- SPECT neuroimaging prior to stopping their medication and again 6 weeks following medication cessation. Autoradiography of post mortem brain tissue with [125I]5-I-A85380 in the presence or absence of four commonly prescribed antidepressants was also assessed. Results: SSRI antidepressants did not affect the relative binding availability of α4β2 nicotinic acetylcholine receptors for the [123I]5-I-A85380 ligand in vivo. Radioligand binding in vitro was unaffected by a single, high pharmacological concentration of antidepressants. Conclusion: SPECT imaging studies using [123I]5-I-A85380 to measure α4β2 nAChR availability in depressed patients are unlikely to be confounded to a major degree by concurrent antidepressant medication.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Pimlott, Dr Sally and Cavanagh, Professor Jonathan and Dewar, Dr Deborah and Patterson, Dr James and Wyper, Professor David
Authors: Cavanagh, J., Patterson, J., Pimlott, S., Wyper, D., and Dewar, D.
Subjects:R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Science and Engineering > School of Physics and Astronomy
Journal Name:Synapse
ISSN:0887-4476
ISSN (Online):1098-2396
Published Online:21 September 2009

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