Koyroytsaltis-McQuire, D. J.P., Gilroy, C., Barron, L. D., Gadegaard, N. , Karimullah, A. S. and Kadodwala, M. (2022) Detecting antibody–antigen interactions with chiral plasmons: factors influencing chiral plasmonic sensing. Advanced Photonics Research, 3(1), 2100155. (doi: 10.1002/adpr.202100155)
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Abstract
Chiral near fields possessing enhanced asymmetry (superchirality), created by the interaction of light with (chiral) nanostructures, potentially provide a route to novel sensing and metrology technologies for biophysical applications. However, the mechanisms by which these near fields lead to the detection of chiral media is still poorly understood. Using a combination of numerical modeling and experimental measurements on an antibody–antigen exemplar system, important factors that influence the efficacy of chiral sensing are illustrated. It is demonstrated that localized and lattice chiral resonances display enantiomeric sensitivity. However, only the localized resonances show a strong dependency on the structure of the chiral media detected. This can be attributed to the ability of birefringent chiral layers to strongly modify the properties of near fields by acting as a sink/source of optical chirality, and hence alter inductive coupling between nanostructure elements. In addition, it is highlighted that surface morphology/defects may amplify sensing capabilities of localized chiral plasmonic modes by mediating inductive coupling.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Koyroytsaltis-McQuire, Dominic and Kadodwala, Professor Malcolm and Karimullah, Dr Affar and Barron, Professor Laurence and Gilroy, Mr Cameron and Gadegaard, Professor Nikolaj |
| Authors: | Koyroytsaltis-McQuire, D. J.P., Gilroy, C., Barron, L. D., Gadegaard, N., Karimullah, A. S., and Kadodwala, M. |
| College/School: | College of Science and Engineering > School of Chemistry College of Science and Engineering > School of Engineering > Biomedical Engineering |
| Journal Name: | Advanced Photonics Research |
| Publisher: | Wiley |
| ISSN: | 2699-9293 |
| ISSN (Online): | 2699-9293 |
| Published Online: | 16 November 2021 |
| Copyright Holders: | Copyright © 2021 The Authors |
| First Published: | First published in Advanced Photonics Research 3(1): 2100155 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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