Salmón, P. , Millet, C., Selman, C. and Monaghan, P. (2021) Growth acceleration results in faster telomere shortening later in life. Proceedings of the Royal Society of London Series B: Biological Sciences, 288(1956), 20211118. (doi: 10.1098/rspb.2021.1118) (PMID:34375555)
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Abstract
There is a wealth of evidence for a lifespan penalty when environmental conditions influence an individual's growth trajectory, such that growth rate is accelerated to attain a target size within a limited time period. Given this empirically demonstrated relationship between accelerated growth and lifespan, and the links between lifespan and telomere dynamics, increased telomere loss could underpin this growth–lifespan trade. We experimentally modified the growth trajectory of nestling zebra finches (Taeniopygia guttata), inducing a group of nestlings to accelerate their growth between 7 and 15 days of age, the main phase of body growth. We then sequentially measured their telomere length in red blood cells at various time points from 7 days to full adulthood (120 days). Accelerated growth between 7 and 15 days was not associated with a detectable increase in telomere shortening during this period compared with controls. However, only in the treatment group induced to show growth acceleration was the rate of growth during the experimental period positively related to the amount of telomere shortening between 15 and 120 days. Our findings provide evidence of a long-term influence of growth rate on later-life telomere shortening, but only when individuals have accelerated growth in response to environmental circumstances.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Monaghan, Professor Pat and Selman, Professor Colin and Millet, Dr Caroline and Salmon, Dr Pablo |
| Creator Roles: | Salmón, P.Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review and editing Millet, C.Data curation, Investigation, Methodology, Writing – review and editing Selman, C.Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review and editing Monaghan, P.Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review and editing |
| Authors: | Salmón, P., Millet, C., Selman, C., and Monaghan, P. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
| Journal Name: | Proceedings of the Royal Society of London Series B: Biological Sciences |
| Publisher: | The Royal Society |
| ISSN: | 0962-8452 |
| ISSN (Online): | 1471-2954 |
| Data DOI: | 10.5061/dryad.d51c59zzn |
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