Orchestrating a heist: uptake and storage of metals by apicomplexan parasites

Sloan, M. A. , Aghabi, D. and Harding, C. R. (2021) Orchestrating a heist: uptake and storage of metals by apicomplexan parasites. Microbiology, 167(12), 001114. (doi: 10.1099/mic.0.001114) (PMID:34898419) (PMCID:PMC7612242)

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The acquisition and storage of metals has been a preoccupation of life for millennia. Transition metals, in particular iron, copper and zinc, have vital roles within cells. However, metals also make dangerous cargos; inappropriate uptake or storage of transition metals leads to cell death. This paradox has led to cells developing elegant and frequently redundant mechanisms for fine-tuning local metal concentrations. In the context of infection, pathogens must overcome further hurdles, as hosts act to weaponize metal availability to prevent pathogen colonization and spread. Here, we detail the methods used by the Apicomplexa, a large family of eukaryotic parasites, to obtain and store essential metals.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Harding, Dr Clare and Sloan, Dr Megan and Aghabi, Ms Dana
Authors: Sloan, M. A., Aghabi, D., and Harding, C. R.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Microbiology
Publisher:Microbiology Society
ISSN (Online):1465-2080
Published Online:13 December 2021
Copyright Holders:Copyright © 2021 The Authors
First Published:First published in Microbiology 167(12): 001114
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
304336Iron usage in the eukaryotic parasite Toxoplasma gondiiClare HardingWellcome Trust (WELLCOTR)213455/Z/18/ZIII - Parasitology