Genome-wide association study identifies susceptibility loci for acute myeloid leukemia

Lin, W.-Y. et al. (2021) Genome-wide association study identifies susceptibility loci for acute myeloid leukemia. Nature Communications, 12, 6233. (doi: 10.1038/s41467-021-26551-x) (PMID:34716350)

Abstract

Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 × 10−8; KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 × 10−10; HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Burnett, Professor Alan
• Authors: Lin, W.-Y., Fordham, S. E., Hungate, E., Sunter, N. J., Elstob, C., Xu, Y., Park, C., Quante, A., Strauch, K., Gieger, C., Skol, A., Rahman, T., Sucheston-Campbell, L., Wang, J., Hahn, T., Clay-Gilmour, A. I., Jones, G. L., Marr, H. J., Jackson, G. H., Menne, T., Collin, M., Ivey, A., Hills, R. K., Burnett, A. K., Russell, N. H., Fitzgibbon, J., Larson, R. A., Le Beau, M. M., Stock, W., Heidenreich, O., Alharbi, A., Allsup, D. J., Houlston, R. S., Norden, J., Dickinson, A. M., Douglas, E., Lendrem, C., Daly, A. K., Palm, L., Piechocki, K., Jeffries, S., Bornhäuser, M., Röllig, C., Altmann, H., Ruhnke, L., Kunadt, D., Wagenführ, L., Cordell, H. J., Darlay, R., Andersen, M. K., Fontana, M. C., Martinelli, G., Marconi, G., Sanz, M. A., Cervera, J., Gómez-Seguí, I., Cluzeau, T., Moreilhon, C., Raynaud, S., Sill, H., Voso, M. T., Lo-Coco, F., Dombret, H., Cheok, M., Preudhomme, C., Gale, R. E., Linch, D., Gaal-Wesinger, J., Masszi, A., Nowak, D., Hofmann, W.-K., Gilkes, A., Porkka, K., Milosevic Feenstra, J. D., Kralovics, R., Grimwade, D., Meggendorfer, M., Haferlach, T., Krizsán, S., Bödör, C., Stölzel, F., Onel, K., and Allan, J. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Nature Communications
• Publisher: Nature Research
• ISSN: 2041-1723
• ISSN (Online): 2041-1723
• Copyright Holders: Copyright © 2021 The Authors
• First Published: First published in Nature Communications 12: 6233
• Publisher Policy: Reproduced under a Creative Commons License